ABSTRACT Inducible acetylation of p53 at lysine residues has a great impact on regulating the transactivation of this protein, which is associated with cell growth arrest and/or apoptosis

under various stress conditions. However, the factor(s) for regulating p53 acetylation remains largely unknown. In the current study, we have shown that p85α, the regulatory subunit of

phosphatidylinositol-3-kinase, has a critical role in mediating p53 acetylation and promoter-specific transactivation in the ultraviolet B (UVB) response. Depletion of p85α in mouse

embryonic fibroblasts significantly impairs UVB-induced apoptosis, as well as p53 transactivation and acetylation at Lys370 (Lys373 of human p53); however, the accumulation, nuclear

UVB-induced expression of the specific p53-responsive gene as well as cell apoptosis. Therefore, we conclude that p85α is a novel regulator of p53-mediated response under certain stress

conditions, and targeting the p85α-dependent p53 pathway may be promising for cancer therapy. Access through your institution Buy or subscribe This is a preview of subscription content,

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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS VPRBP/DCAF1 REGULATES P53 FUNCTION AND STABILITY

THROUGH SITE-SPECIFIC PHOSPHORYLATION Article Open access 11 April 2023 DECIPHERING THE ACETYLATION CODE OF P53 IN TRANSCRIPTION REGULATION AND TUMOR SUPPRESSION Article 29 April 2022 A

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manner. _Hepatology_ 49: 504–512. Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS We appreciate the technical help from Dr Dan Liu and the helpful discussion

provided by Dr Ailing Li. This project is partially supported by NIH/NCI CA112557, CA119028-05S110, NIH/NIEHS ES010344 and ES012451 (to Dr C Huang); and National Natural Science Foundation

of China No. 30871277, 30970594, Beijing Natural Science Foundation 5092022 and 5102035 and the National Key Research and Development Programs on Fundamental Sciences (973 Project)

2011CB503803 (to Dr L Song). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Environmental Medicine, Nelson Institute of Environmental Medicine, New York University School of

Medicine, Tuxedo, NY, USA L Song, J Li, X Shi & C Huang * Department of Cellular Immunology, Beijing Institute of Basic Medical Sciences, Beijing, People's Republic of China L Song,

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or C Huang. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Song,

L., Gao, M., Dong, W. _et al._ p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. _Oncogene_ 30, 1360–1371 (2011).

https://doi.org/10.1038/onc.2010.506 Download citation * Received: 03 April 2010 * Revised: 26 September 2010 * Accepted: 26 September 2010 * Published: 08 November 2010 * Issue Date: 17

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