ABSTRACT The objective of this study was to test a novel technique of processing a prostate biopsy (PB) specimen by marking its peripheral end (PE) as a predictive tool for locally advanced

prostate cancer (PC) or margin-positive resection (R1) after radical prostatectomy (RP). Prospective evaluation of a consecutive cohort of men who underwent PB and subsequent RP was carried

out. Transrectal ultrasound-guided 10–20 core PB was performed according to a standardized protocol. Each biopsy core was inked at the PE and classified as PE positive or negative. The study

cohort comprised 100 men with a mean age of 62.3 years (41–75 years). Overall, PE-positive cores were found in 71 men, postoperative tumour (pT)3/pT4 stages were diagnosed in 33 men and R1

positivity and PSA, PE positivity was correlated to pT3/pT4 stage (_P_=0.04). In conclusion, PC at the PE of a PB specimen predicts non-organ-confined tumour stage in subsequent

prostatectomy. This simple, new technique may contribute to increasing the accuracy of risk stratification for curative treatment of PC. Access through your institution Buy or subscribe This

is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 4 print issues and online access $259.00

per year only $64.75 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated

during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS PREDICTION OF

SURGICAL MARGIN STATUS AND LOCATION AFTER RADICAL PROSTATECTOMY USING POSITIVE BIOPSY SITES ON 12-CORE STANDARD PROSTATE BIOPSY Article Open access 08 March 2022 PREOPERATIVE PSMA-PET/CT AS

A PREDICTOR OF BIOCHEMICAL PERSISTENCE AND EARLY RECURRENCE FOLLOWING RADICAL PROSTATECTOMY WITH LYMPH NODE DISSECTION Article 01 September 2021 MRI LESION SIZE IS MORE IMPORTANT THAN THE

NUMBER OF POSITIVE BIOPSY CORES IN PREDICTING ADVERSE FEATURES AND RECURRENCE AFTER RADICAL PROSTATECTOMY: IMPLICATIONS FOR ACTIVE SURVEILLANCE CRITERIA IN INTERMEDIATE-RISK PATIENTS Article

14 July 2023 REFERENCES * Heidenreich A, Bolla M, Joniau S, Aus G, Matveev VB, Schmid HP _et al_. EAU guidelines on prostate cancer. _EAU_ 2009; 33: 113–126. Google Scholar  * Montironi R,

Mazzucchelli R, Scarpelli M, Lopez-Beltran A, Mikuz G, Algaba F _et al_. Prostate carcinoma II: prognostic factors in prostate needle biopsies. _BJU Int_ 2006; 97: 492–497. Article  PubMed 

Google Scholar  * Epstein JI, Allsbrook Jr WC, Amin MB, Egevad LL . The 2005 International Society of Urologic Pathology (ISUP) Consensus Conference on Gleason grading of Prostatic

Carcinoma. _Am J Surg Pathol_ 2005; 29: 1228–1242. Article  PubMed  Google Scholar  * Grossklaus DJ, Coffey CS, Shappell SB, Jack GS, Chang SS, Cookson MS . Percent of cancer in the biopsy

set predicts pathological findings after prostatectomy. _J Urol_ 2002; 167: 2032–2035. Article  PubMed  Google Scholar  * Freedland SJ, Terris MK, Csathy GL, Kane CJ, Amling CL, Presti Jr JC

_et al_. Preoperative model for predicting prostate specific antigen recurrence after radical prostatectomy using percent of biopsy tissue with cancer, biopsy Gleason grade and serum

prostate specific antigen. _J Urol_ 2004; 171 (6 Part 1): 2215–2220. Article  PubMed  Google Scholar  * Sebo TJ, Cheville JC, Riehle DL, Lohse CM, Pankratz VS, Myers RP _et al_. Predicting

prostate carcinoma volume and stage at radical prostatectomy by assessing needle biopsy specimens for percent surface area and cores positive for carcinoma, perineural invasion, Gleason

score, DANN ploidy and proliferation, and preoperative serum prostate specific antigen: a report of 454 cases. _Cancer_ 2001; 91: 2196–2204. Article  CAS  PubMed  Google Scholar  * Partin

AW, Kattan MW, Subong EN, Walsh PC, Wojno KJ, Oesterling JE _et al_. Combination of PSA, clinical stage and Gleason score to predict pathological stage of localized prostate cancer: A

multi-institutional update. _JAMA_ 1997; 277: 1445–1451. Article  CAS  PubMed  Google Scholar  * Walsh PC, De Weese TL, Eisenberger MA . Localized prostate cancer. _N Engl J Med_ 2007; 357:

2696–2705. Article  CAS  PubMed  Google Scholar  * Kattan MW, Stapleton AM, Wheeler TM, Scardino PT . Evaluation of a nomogram used to predict pathological stage of clinically localized

prostate carcinoma. _Cancer_ 1997; 79: 528–537. Article  CAS  PubMed  Google Scholar  * Scattoni V, Zlotta A, Montironi E, Schulman C, Rigatti P, Montorsi F . Extended and saturation

prostatic biopsy in the diagnosis and characterization of prostate cancer: a critical analysis of the literature. _Eur Urol_ 2007; 52: 1309–1322. Article  PubMed  Google Scholar  * D’Amico

AV, Wu Y, Chen MH, Nash M, Renshaw AA, Richie JP . Perineural invasion as a predictor of biochemical outcome following radical prostatectomy for selected men with clinically localized

prostate cancer. _J Urol_ 2001; 165: 126–129. Article  PubMed  Google Scholar  * de la Taille A, Katz A, Bagiella E, Olsson CA, O'Toole KM, Rubin MA . Perineural invasion in prostate

needle biopsy: an independent predictor for final pathological stage. _Urology_ 1999; 54: 1039–1044. Article  CAS  PubMed  Google Scholar  * Descazeaud A, Rubin MA, Allory Y, Burchardt M,

Salomon L, Chopin D . What information are urologists extracting from needle biopsy reports and what do they need for clinical management of prostate cancer? _Eur Urol_ 2005; 48: 911–915.

Article  PubMed  Google Scholar  * Joseph T, McKenna DA, Westphalen AC, Coakley FV, Zhao S, Lu Y _et al_. Pretreatment endorectal magnetic imaging and magnetic resonance spectroscopic

imaging features of PC as predictors of response to external beam radiotherapy. _Int J Radiat Oncol Biol Phys_ 2009; 73: 665–672. Article  PubMed  Google Scholar  * Guillonneau B, El-fettouh

H, Baumert H, Cathelineau X, Doublet JD, Fromont G _et al_. Laparoscopic radical prostatectomy: oncologic evaluation after 1000 cases at Montsouris Institute. _J Urol_ 2003; 169: 1261–1266.

Article  CAS  PubMed  Google Scholar  * Stolzenburg JU, Rabenalt R, Do M, Truss MC, Burchardt M, Herrmann TR _et al_. Endoscopic extraperitoneal radical prostatectomy: the University of

leipzig experience of 1300 cases. _World J Urol_ 2007; 25: 45–51. Article  PubMed  Google Scholar  * Han M, Partin AW, Pound CR, Epstein JI, Walsh PC . Long term biochemical disease-free and

cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-years Johns Hopkins experience. _Urol Clin North Am_ 2001; 28: 555–565. Article  CAS  PubMed  Google

Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Urology and Andrology, Hospital Saint John of God, Vienna, Austria A Ponholzer * Department of

Urology and Andrology, Danube Hospital, Vienna, Austria M Rauchenwald & S Madersbacher * Institute of Pathology, Danube Hospital, Vienna, Austria A Rainer-Concin & B Hummer *

Urological Private Practice, Vienna, Austria K Fink * Department of Urology, Hospital Saint John of God, Salzburg, Austria R Szlauer & N Schmeller Authors * A Ponholzer View author

publications You can also search for this author inPubMed Google Scholar * M Rauchenwald View author publications You can also search for this author inPubMed Google Scholar * A

Rainer-Concin View author publications You can also search for this author inPubMed Google Scholar * B Hummer View author publications You can also search for this author inPubMed Google

Scholar * K Fink View author publications You can also search for this author inPubMed Google Scholar * R Szlauer View author publications You can also search for this author inPubMed Google

Scholar * N Schmeller View author publications You can also search for this author inPubMed Google Scholar * S Madersbacher View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A Ponholzer. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ponholzer, A., Rauchenwald, M., Rainer-Concin, A. _et al._ Prostate cancer at the peripheral end of a prostate biopsy specimen

as assessed by a novel marking technique may indicate increased risk of locally advanced disease. _Prostate Cancer Prostatic Dis_ 14, 69–73 (2011). https://doi.org/10.1038/pcan.2010.40

Download citation * Received: 25 June 2010 * Revised: 16 August 2010 * Accepted: 17 August 2010 * Published: 09 November 2010 * Issue Date: March 2011 * DOI:

https://doi.org/10.1038/pcan.2010.40 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * biopsy * staging * histology