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ABSTRACT 16 patients with XO-syndrome, aged 11.1 - 16.3 years, were treated with 0.1 mg/kg oxandrolone daily. Mean bone age 11.3 ± 1.1 (SD) years, height SDS (standard deviation score) for
chronological age 3.45 ± 0.94. Pat. received oxandrolone therapy for one year (period I), no therapy for the next 6 months (period II) and oxandrolone again for further six-month periods
(period III, IV). There was a significant increase (p < 0.005) in growth velocity (cm/year) with hormone medication: pretreatment: 2.3 ± 1.2, during first and second 6 months of therapy:
5.9 ± 1.6 and 5.2 ± 0.9, during period II: 1.4 ± 1.1, period III: 4.6 ± 1.4, period IV: 4.0 ± 0.5. Bone age velocity did not differ significantly from pretreatment velocity during period
I-IV. Oxandrolone treatment resulted in a significant increase (p < 0.005) in the ratio of height age: bone age. Height SDS for bone age significantly decreased (p < 0.01) with hormone
administration: pretreatment: −1.72 ± 0.76, after period I: −1.41 ± 0.76, after period II: −1.69 ± 0.75, after period III: −1.49 ± 0.66 and after period IV: −1751 ± 0.62. Serious
side-effects were not observed. These data may suggest some favourable effect of oxandrolone on growth in Turner's syndrome. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *
Dept. of Pediatrics, University of Hamburg, Germany N Stahnke & R P Willig Authors * N Stahnke View author publications You can also search for this author inPubMed Google Scholar * R P
Willig View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Stahnke, N.,
Willig, R. Effects of Oxandrolone on Growth in Turner's Syndrome. _Pediatr Res_ 13, 1194 (1979). https://doi.org/10.1203/00006450-197910000-00085 Download citation * Issue Date: 01
October 1979 * DOI: https://doi.org/10.1203/00006450-197910000-00085 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry,
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