Determining role of the optic vesicle in orbital and periocular development and placement

Determining role of the optic vesicle in orbital and periocular development and placement

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ABSTRACT Summary: Nine patients with aberrations in development and placement of the eyes and periocular structures who also had serious defects in central nervous system development were evaluated in order to better understand normal ocular development. Included were an incompletely developed twin stillborn infant who lacked both eyes and the nose, a stillborn infant with cyclopia bypognathia, 6 spontaneous abortuses with varying degrees of holoprosencephaly, and a 17-year-old male with a serious defect in central nervous system development whose right eye was positioned laterally above the right ear. In all cases, evidence indicates that orbital and periocular structures are determined by the underlying optic vesicle rather than independently derived as has been suggested by previous studies. Speculation: The intimate developmental relationship between the forebrain and structures of the upper face suggests that alterations of periocular and bony orbital structure and placement may well reflect defects in underlying brain development. SIMILAR CONTENT BEING VIEWED BY OTHERS TOPOGRAPHICAL ANATOMY OF THE ANNULUS OF ZINN Article Open access 20 January 2022 THE VARIETIES OF JUNCTIONAL SCOTOMA: 17 CASES, A REVIEW, AND A TAXONOMY Article 22 April 2025 ORBITAL APEX ANATOMY: RELATIONSHIP BETWEEN THE OPTIC FORAMEN AND ANTERIOR FACE OF SPHENOID SINUS — A RADIOLOGICAL STUDY Article 22 November 2020 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, 92093, California, USA Kenneth Lyons Jones & Marilyn C Higginbottom * Department of Pediatrics, Dysmorphology Unit, University of Washington School of Medicine, Seattle, Washington, USA David W Smith Authors * Kenneth Lyons Jones View author publications You can also search for this author inPubMed Google Scholar * Marilyn C Higginbottom View author publications You can also search for this author inPubMed Google Scholar * David W Smith View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jones, K., Higginbottom, M. & Smith, D. Determining Role of the Optic Vesicle in Orbital and Periocular Development and Placement. _Pediatr Res_ 14, 703–708 (1980). https://doi.org/10.1203/00006450-198005000-00001 Download citation * Issue Date: 01 May 1980 * DOI: https://doi.org/10.1203/00006450-198005000-00001 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * bony orbital structures * central nervous system defects * development * optic nerve * periocular structures

ABSTRACT Summary: Nine patients with aberrations in development and placement of the eyes and periocular structures who also had serious defects in central nervous system development were


evaluated in order to better understand normal ocular development. Included were an incompletely developed twin stillborn infant who lacked both eyes and the nose, a stillborn infant with


cyclopia bypognathia, 6 spontaneous abortuses with varying degrees of holoprosencephaly, and a 17-year-old male with a serious defect in central nervous system development whose right eye


was positioned laterally above the right ear. In all cases, evidence indicates that orbital and periocular structures are determined by the underlying optic vesicle rather than independently


derived as has been suggested by previous studies. Speculation: The intimate developmental relationship between the forebrain and structures of the upper face suggests that alterations of


periocular and bony orbital structure and placement may well reflect defects in underlying brain development. SIMILAR CONTENT BEING VIEWED BY OTHERS TOPOGRAPHICAL ANATOMY OF THE ANNULUS OF


ZINN Article Open access 20 January 2022 THE VARIETIES OF JUNCTIONAL SCOTOMA: 17 CASES, A REVIEW, AND A TAXONOMY Article 22 April 2025 ORBITAL APEX ANATOMY: RELATIONSHIP BETWEEN THE OPTIC


FORAMEN AND ANTERIOR FACE OF SPHENOID SINUS — A RADIOLOGICAL STUDY Article 22 November 2020 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of


California, San Diego School of Medicine, La Jolla, 92093, California, USA Kenneth Lyons Jones & Marilyn C Higginbottom * Department of Pediatrics, Dysmorphology Unit, University of


Washington School of Medicine, Seattle, Washington, USA David W Smith Authors * Kenneth Lyons Jones View author publications You can also search for this author inPubMed Google Scholar *


Marilyn C Higginbottom View author publications You can also search for this author inPubMed Google Scholar * David W Smith View author publications You can also search for this author


inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jones, K., Higginbottom, M. & Smith, D. Determining Role of the Optic Vesicle


in Orbital and Periocular Development and Placement. _Pediatr Res_ 14, 703–708 (1980). https://doi.org/10.1203/00006450-198005000-00001 Download citation * Issue Date: 01 May 1980 * DOI:


https://doi.org/10.1203/00006450-198005000-00001 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is


not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * bony orbital structures * central nervous system


defects * development * optic nerve * periocular structures