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ABSTRACT Prior studies of RBC glycolytic enzymes in term infants on the first day of life have revealed elevated levels of phosphoglycerate kinase (PGK) and enolase (ENO) and decreased
activity of phosphofructokinase (PFK) when compared to both RBC's from normal adults and subjects with a RBC population of a similar young mean cell age, as reflected in pyruvate kinase
(PK) activity. In the present study, 25 premature infants were studied on the first day of life to determine whether this increase in RBC PGK and ENO and decrease in PFK activities are
greater in the preterm infant and vary with gestational age. There were 3 groups: 9 infants 28-30 wks of age; 9 of 31-33 wks and 7 of 34-36 wks. The age-dependent enzymes PK, hexokinase and
aldolase were higher in premature infants than term infants indicating a RBC population of a younger mean cell age. The mean activities of both PGK and ENO were also higher in the premature
infants than in term infants but did not differ significantly between 28-30 wks to 34-36 wks. Mean PFK activity, however, was higher, not lower in premature infants than in term infants. In
contrast to term infants, PFK activity correlated well with the age-dependent enzyme, PK (r=0.73; p<0.001). Thus, it appears that the young mean RBC population present in the premature
infant on the first day of life significantly influences PFK activity, resulting in higher levels than those anticipated at such a young gestational age. ARTICLE PDF AUTHOR INFORMATION
AUTHORS AND AFFILIATIONS * Thos. Jeff. Univ., Dept. Ped. and Cardeza Fdn. and Univ. Penna. Med. School, Dept. Ped. and Physiol., Philadelphia, PA Susan F Travis, Patricia L O'Neal,
Savitri P Kumar & Maria Delivorla-Papadopoulos Authors * Susan F Travis View author publications You can also search for this author inPubMed Google Scholar * Patricia L O'Neal View
author publications You can also search for this author inPubMed Google Scholar * Savitri P Kumar View author publications You can also search for this author inPubMed Google Scholar *
Maria Delivorla-Papadopoulos View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS
ARTICLE Travis, S., O'Neal, P., Kumar, S. _et al._ 884 GLYCOLYTIC ENZYMES IN PREMATURE INFANTS ON THE FIRST DAY OF LIFE. _Pediatr Res_ 15 (Suppl 4), 590 (1981).
https://doi.org/10.1203/00006450-198104001-00909 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00909 SHARE THIS ARTICLE Anyone you share the
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