904 double light chain production by leukemic cells of common clonal origin

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ABSTRACT Generally lympho-plasmacytic malignancies are of monoclonal origin in that neoplastic B cells produce immunoglobulin (Ig) composed of a single class of heavy and light chains. Thus

the presence of more than one monotypic Ig on the surface and in the cytoplasm of the neoplastic cells of a patient constitutes an uncommon event. We are presenting an 11 year old boy with

acute lymphoblastic leukemia of the rare B-cell type in which the same neoplastic cells produced both κ and τ light chains without any heavy chains as demonstrated by double

immunofluorescence. There was evidence of secretion of both κ and τ light chains in cultures of the leukemic cells. Secretion of both light chains into the blood was also demonstrated at

postmortem examination. Although the production of more than a single class of Ig has been known to occur in rare cases of multiple myeloma and Waldenstrom's macroglobulinemia, such an

event has not been reported in patients with leukemia or lymphoma. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pathology and Pediatrics, Martha Wong Albert

Einstein College of Medicine, The Bronx-Lebanon Hospital Center, Bronx, New York Young J Choi & M Cohen Authors * Young J Choi View author publications You can also search for this

author inPubMed Google Scholar * M Cohen View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Choi, Y., Cohen, M. 904 DOUBLE LIGHT CHAIN PRODUCTION BY LEUKEMIC CELLS OF COMMON CLONAL ORIGIN. _Pediatr Res_ 15 (Suppl 4), 593 (1981).

https://doi.org/10.1203/00006450-198104001-00929 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00929 SHARE THIS ARTICLE Anyone you share the

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