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ABSTRACT The somatomedins (SM) are a group of peptide hormones which are believed to mediate at least some of growth hormone's anabolic effects. While the role of SM in postnatal growth
is well established, its function in prenatal and early postnatal growth is not clear and studies on SM levels in the neonatal period have given conflicting results. Part of the confusion
is due to the fact that the assays employed are relatively nonspecific for the different SMs. We have used a highly specific immunoassay to measure SM-C levels in 18 healthy full term
neonates (birth weight 2750-3825 gm). SM-C was measured on cord blood (CB) and on samples obtained on days 1,2,3,4,5 and 14. Relative to normal adult serum (1 μ/ml) the CB levels were low
(0.27 ± .21) and fell to almost undetectable levels within the first day (< 0.1). SM-C levels remained low through day 4 but began to rise on the 5th day (.19 ± .09). By day 14 the levels
were above those seen in cord serum (0.47 ± .28). The low SM-C levels observed in early postnatal life, a period when growth hormone levels are elevated, suggests a relative insensitivity
of the neonate to the somatogenic effects of growth hormone. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, (Spon. by Walter J. Meyer III). University of
Texas Medical Branch Hospitals, Galveston Casey G Falterman, Richard W Furlanetto, C Joan Richardson & M Cassandra Matustik Authors * Casey G Falterman View author publications You can
also search for this author inPubMed Google Scholar * Richard W Furlanetto View author publications You can also search for this author inPubMed Google Scholar * C Joan Richardson View
author publications You can also search for this author inPubMed Google Scholar * M Cassandra Matustik View author publications You can also search for this author inPubMed Google Scholar
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Falterman, C., Furlanetto, R., Richardson, C. _et al._ 1299 SOMATOMEDIN-C (SM-C) IN THE NEONATE. _Pediatr
Res_ 15 (Suppl 4), 659 (1981). https://doi.org/10.1203/00006450-198104001-01328 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01328 SHARE
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