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ABSTRACT The potential use of a piglet as a model for investigation of brain blood flow (BBF) was evaluated by assessing the presence of autoregulation in 11 spontaneously breathing newborn
piglets. MABP was altered by phlebotomy. Within the normotensive range (MABP=51-105 mmHg) no significant change in BBF (measured by the microsphere technique)occurred (r=0.03) indicating the
presence of autoregulation. During hypotension (MABP=15-50 mmHg), a pressure passive relation exists between BBF and MABP (r=0.59). However, since the piglets breathed spontaneously and
hyperventilated during hypotension, both the MABP and PaCO2 fell and both correlated with BBF during hypotension. Thus, it is uncertain which factor is responsible for the loss of
autoregulation. The blood flow (BF) to three specific regions of the brain (cerebrum, cerebellum, brainstem) and MABP also showed no correlation during normotension. During hypotension each
region demonstrates significant pressure passive relationships, but the reduction in BF is most pronounced in the cerebrum, less in the cerebellum, and least in the brainstem, (M±SE, 58±7%,
34±12%, 27±11% reduction from control respectively, p<.05). The study indicates that a newborn piglet may serve as an appropriate model for the study of brain hemodynamics particularly
with regard to autoregulation. Furthermore, during hypotension, preferential protection of vital regions of the brain (cerebellum and brainstem) occur which may have important implication in
interpreting the effect of hypotension on the newborn central nervous system. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Brown Univ. Program in Medicine, Women S Infants
Hosp., Dept. of Ped., Providence, RI A Laptook, B S Stonestreet & W Oh Authors * A Laptook View author publications You can also search for this author inPubMed Google Scholar * B S
Stonestreet View author publications You can also search for this author inPubMed Google Scholar * W Oh View author publications You can also search for this author inPubMed Google Scholar
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Laptook, A., Stonestreet, B. & Oh, W. 1585 AUTOREGULATION OF BRAIN BLOOD FLOW (BBF): REGIONAL
DIFFERENCES IN REDUCED BBP WITH HYPOTENSION. _Pediatr Res_ 15 (Suppl 4), 707 (1981). https://doi.org/10.1203/00006450-198104001-01602 Download citation * Issue Date: 01 April 1981 * DOI:
https://doi.org/10.1203/00006450-198104001-01602 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is
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