Play all audios:
ABSTRACT Mean airway pressure (MAP) directly relates to oxygenation in neonates with respiratory distress syndrome (RDS). Variations in the Positive End Expiratory Pressure(PEEP)with
concomitant changes of the Duration of Positive Pressure (DPP) while MAP, Peak Inspiratory Pressure, flow, FiO2 and rate remained constant, were investigated in 9 neonates with RDS during
the 1st and 2nd day of life. After stabilization on baseline ventilator settings, PEEP was increased by an average of 60% and the DPP was decreased (about 0.3 sec)in order to maintain
baseline MAP. Following a return to baseline,a second experimental condition consisted of decreasing PEEP by 60%, increasing DPP accordingly to maintain constant MAP. Arterial BP, heart
rate, paO2, paCO2, pH and arterial/Alveolar pO2 ratios (a/APO2) were measured before, during, between and after the experimental conditions. Analysis of the data revealed no significant
changes in BP, paO2, a/APO2, heart rate during baseline or experimental conditions. PaCO2 decreased significantly when PEEP was decreased and DPP increased, both on Day 1(37.2 ± 6.6 vs 41.4
± 6.4 Torr; p<.025)and Day 2(42.1 ± 7.4 vs 46.8 ± 5.6 Torr; p<.05). The changes in pH were inversely related to paCO2 changes. Air leaks occurred in 2 neonates who had MAP greater than
12cmH2O which was statistically higher than MAP in neonates without air leaks(12.9 vs 8.8cmH20;p<.025).This study confirms the importance of MAP in determining oxygenation in neonates
with RDS. However, ventilation was significantly affected by variation in PEEP and DPP despite a constant MAP. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Miller
Children's Hosp, Long Beach, CA. Thomas A Ciszek, Houchang D Modanlou & Donald Owings Authors * Thomas A Ciszek View author publications You can also search for this author inPubMed
Google Scholar * Houchang D Modanlou View author publications You can also search for this author inPubMed Google Scholar * Donald Owings View author publications You can also search for
this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ciszek, T., Modanlou, H. & Owings, D. 1636 MEAN AIRWAY
PRESSURE-SIGNIFICANCE DURING ASSISTED VEN-TILATION. _Pediatr Res_ 15 (Suppl 4), 716 (1981). https://doi.org/10.1203/00006450-198104001-01653 Download citation * Issue Date: 01 April 1981 *
DOI: https://doi.org/10.1203/00006450-198104001-01653 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable
link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative