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ABSTRACT This study was designed to determine cardiopulmonary responses to nasal obstruction in different sleep states. 8 healthy preterm infants (wt 1.8±.1Kg) were studied at a corrected
G.A. of 35±2 wks by multiple 10 sec occlusions during active (AS) and quiet (QS) sleep, via nasal prongs fitted with a thermistor to measure airflow. Heart rate (HR), mouth airflow,
transcutaneous PO2 (Tc PO2), chest wall movements, respiratory frequency (f) and sleep state were continuously monitored. Nasal occlusion was invariably accompanied by a fall in TcPO2, which
was greater during AS than QS (8±2 vs 5±3 mmHg, p<.01). In contrast, HR fell with only 54% of occlusions, more in AS than QS (35±15 vs 21±7/min, p<.05). During obstruction the
frequency of respiratory efforts decreased from 45±10 to 35±7/min (p<.001) compared to preocclusion levels, while mouth airflow was only sporadic and did not influence the fall in TcPO2
or HR. In the initial 5 sec following occlusion, f returned to preocclusion levels. During the subsequent 5 sec, f decreased from 47±10 to 35±13/min (p<.03) in AS and from 41±9 to
31±16/min (p<.03) in QS, as compared to preocclusion levels. Furtheremore, in the 20 sec following occlusion (vs preocclusion) the duration of respiratory pauses ≥2 sec increased in both
AS and QS (p<.01). We conclude that 1) preterm infants are more vulnerable to nasal obstruction in AS with a greater fall in PO2 and HR, 2) airway obstruction may enhance susceptibility
to the subsequent development of central apnea, and 3) since obstruction may not be accompanied by a fall in HR, routine cardio-respiratory monitoring may fail to detect many episodes.
ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dept. of Ped., CWRU, Cleveland, Ohio R J Martin, F G A Versteegh, W A Carlo, J V Anderson & E N Bruce Authors * R J Martin View
author publications You can also search for this author inPubMed Google Scholar * F G A Versteegh View author publications You can also search for this author inPubMed Google Scholar * W A
Carlo View author publications You can also search for this author inPubMed Google Scholar * J V Anderson View author publications You can also search for this author inPubMed Google Scholar
* E N Bruce View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Martin,
R., Versteegh, F., Carlo, W. _et al._ 1695 VULNERABILITY OF PRETERM INFANTS TO NASAL OBSTRUCTION. _Pediatr Res_ 15 (Suppl 4), 726 (1981). https://doi.org/10.1203/00006450-198104001-01714
Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01714 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this
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