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ABSTRACT Catecholamine (CAT) release has been observed in near term fetal sheep in response to a variety of stimuli including hypoxia, maternal hypovolemia or exercise and parturition. In
earlier studies of fetal sympatho-adrenal activity in response to parturition it has not been possible to differentiate the effects of labor, intrapartum asphyxia, delivery and UCC on CAT
release. We have used the acutely exteriorized near term fetal lamb to study the effects of delivery and UCC on CAT release. Results show that delivery alone evokes an elevation of newborn
plasma CAT which is brief and followed by return to basal values by 30 min. Subsequent UCC evokes a marked release of norepinephrine (NE) and epinephrine (E) (peak plasma levels 32,000 pg/ml
and 35,000 pg/ml), maximal at 5 min. and persisting over the 4 hour study period. There is a concomitant rise in plasma free fatty acids (FFA) and reversal of post-delivery hypothermia. The
magnitude of the CAT surge is inversely proportional to the degree of acidosis; a blunted FFA response and slower correction of hypothermia were observed in more acidotic animals despite
higher CAT levels. Conclusions: 1) UCC is an important stimulus for fetal CAT release. 2) UCC stimulated neurosympathetic activity is of sufficient magnitude to influence many metabolic and
cardiovascular functions. 3) Acidosis stimulates CAT release in the near term ovine fetus. 4) Acidosis obtunds neonatal chemical thermogenesis. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND
AFFILIATIONS * Departments of Pediatrics and Obstetrics-Gynecology, UCLA School of Medicine, Harbor-UCLA Medical Cenler, Torrance, CA. James F Padbury, Emmanuel S Diakomanolis, Calvin J
Hobel, Alvin Perelman & Delbert A Fisher Authors * James F Padbury View author publications You can also search for this author inPubMed Google Scholar * Emmanuel S Diakomanolis View
author publications You can also search for this author inPubMed Google Scholar * Calvin J Hobel View author publications You can also search for this author inPubMed Google Scholar * Alvin
Perelman View author publications You can also search for this author inPubMed Google Scholar * Delbert A Fisher View author publications You can also search for this author inPubMed Google
Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Padbury, J., Diakomanolis, E., Hobel, C. _et al._ 279 SYMPATHO-ADRENAL RESPONSE TO UMBILICAL CORD
CUTTING (UCC). _Pediatr Res_ 15 (Suppl 4), 486 (1981). https://doi.org/10.1203/00006450-198104001-00290 Download citation * Issue Date: 01 April 1981 * DOI:
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