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ABSTRACT A-II was infused in 17 chronically catheterized fetal (F) lambs (116-131 days gestation) and in 7 nonpregnant adult (A) ewes. The rates of A-II infusion in F and A were adjusted to
compare the effect of similar plasma A-II concentrations (pA-II) on plasma Aldo, PRA, arterial pressure (MABP); it was found that the rate of A-II infusion had to be about 5 times higher in
F than in A to reach similar pA-II. The effect of A-II infusion in F and A were studied at 3 different levels of pA-II. (* for p<0.05 when values during A-II infusion are compared to
control values; † for p<0.05 when pA-II values in F are compared to A values.) The A-II plasma clearance rate was significantly (p<0.001) higher in F (179±16 ml/min/kg) than in A (40±3
ml/min/kg). The present results indicate that A-II stimulates Aldo and inhibits renin production in fetal life. It is also suggested that the responsiveness to an increased concentration of
pA-II is lower in F than A. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Universtiy of Iowa, Dept Pediatrics, Iowa City, IA. J E Robillard & F G Smith Authors * J E
Robillard View author publications You can also search for this author inPubMed Google Scholar * F G Smith View author publications You can also search for this author inPubMed Google
Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Robillard, J., Smith, F. 286 MODULATION OF PLASMA ALDOSTERNONE (Aldo) CONCENTRATION AND PLASMA
RENIN ACTIVITY (PRA) BY ANGIOTENSIN-II (A-II) DURING FETAL LIFE. _Pediatr Res_ 15 (Suppl 4), 487 (1981). https://doi.org/10.1203/00006450-198104001-00297 Download citation * Issue Date: 01
April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00297 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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