Play all audios:
ABSTRACT Gonadal functions are frequently disturbed in adults with CRF submitted to dialysis. The degree of pubertal maturation was investigated in boys whose CRF was treated either by
dialysis (group D, n = 14) or by renal transplantation (group T, n = 12), divided according to age: 1 = 9 to 13 years, 2 = over 13 years. Testosterone (T) levels (nmol/l, x̄ ± sem) in D1:
0.71 ± 0.43 (mean age 11.7) and in T1: 0.24 ± 0.16 (mean age 12.4) were significantly lower than in normal boys. In D2: 5.2 ± 1.8 (mean age 14.6) and T2: 16.5 ± 5.5 (mean age 17.5) they did
not differ from normal. When plotted against bone age, T levels were generally above the normal mean. LH levels (IU/1) were high in D1 (7.4 ± 1.1) and D2 (5.2 ± 1.3) without any correlation
with T levels, but normal in T1 (1.1 ± 0.3) and T2 (2.9 ± 0.4). Androstenedione levels (nmol/l) were low in all subgroups: D1 0.79 ± 0.26, D2 1.3 ± 0.3, T1 0.18 ± 0.09, T2 1.3 ± 0.2, but did
not differ from normal when plotted against bone age. Dehydroepiandrosterone levels (nmol/l) were low relatively to age: D1 0.97 ± 0.31, D2 3.6 ± 1.1, T1 0.62 ± 0.22, T2 5.4 ± 2.7. This
deficiency was corrected when plotted against height age. These data give evidence of a delayed testis maturation with abnormal LH secretion in dialysed boys and a deficient adrenal
androgenic production possibly related to the low body mass. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Fondation de Recherche en Hormonologie, Paris, France M Roger, M
Broyer, K Schärer, J Usberti & M Castanier * Hôpital des Enfants Malades, Paris, France M Roger, M Broyer, K Schärer, J Usberti & M Castanier * Kinderkilnik der Universität
Heidelberg, Germany M Roger, M Broyer, K Schärer, J Usberti & M Castanier Authors * M Roger View author publications You can also search for this author inPubMed Google Scholar * M
Broyer View author publications You can also search for this author inPubMed Google Scholar * K Schärer View author publications You can also search for this author inPubMed Google Scholar *
J Usberti View author publications You can also search for this author inPubMed Google Scholar * M Castanier View author publications You can also search for this author inPubMed Google
Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Roger, M., Broyer, M., Schärer, K. _et al._ Gonadptropin and androgen levels in boys with chronic
renal failure (CRF). Evidence of multiple androgenic deficiencies. _Pediatr Res_ 15, 87 (1981). https://doi.org/10.1203/00006450-198101000-00096 Download citation * Issue Date: 01 January
1981 * DOI: https://doi.org/10.1203/00006450-198101000-00096 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative