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ABSTRACT Six wk. old male & female rats were gavaged daily with either Basaljel (lml/100gm body wt.) or distilled water for 3 wks. Baseline, 1 wk. & 3 wk., values for serum
phosphorus (Pi) in 10 Basaljel-treated females (BTF) were 7.4±0.1, 6.4±0.3, & 6.3 mg/dl respectively; corresponding values for 10 Basaljel-treated males (BTM) of 8.2±0.1, 7.3±0.2, &
7.4±0.2 mg/dl were significantly higher (p<0.05). By 1 wk. of therapy, serum Pi of BTF was lower than that of 10 female controls (p<0.025); serum Pi values of BTM and 10 male controls
were similar even after 3 wks. of therapy. Serum calcium of the BTF after 3 wks. was higher than female controls 10.5±0.1 vs 9.9±0.2 mg/dl (p<0.025); values in BTM did not differ from
male controls. After 3 wks. of treatment BTF had significant elevation in urinary calcium (p < 0.025) & decreases in urinary CAMP (p<0.025) when compared to BTM. In vitro (32PO4)
absorption by isolated duodenal and jejunal loops during Pi depletion was similar in BTF & BTM whereas initially absorption into mucosa was higher in BTM compared to BTF (p < 0.05).
Summary: In contrast to the male, phosphate depletion in female rats results in hypercalcemia, hypophosphatemia, & decreased urinary CAMP. These findings are probably dependent on sex
differences in parathyroid hormone secretion and vitamin D metabolism. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * St. Louis Univ. School of Medicine, Cardinal Glennon Memorial
Hospital for Children, Dept. of Pediatrics, St. Louis Kathleen B Schwarz, Debra C Zimmerman, Max Zahn, David H Alpers, Louis V Avioli & Patricia Monteleone * Washington Univ. School of
Medicine, Dept. of Medicine, St. Louis Kathleen B Schwarz, Debra C Zimmerman, Max Zahn, David H Alpers, Louis V Avioli & Patricia Monteleone Authors * Kathleen B Schwarz View author
publications You can also search for this author inPubMed Google Scholar * Debra C Zimmerman View author publications You can also search for this author inPubMed Google Scholar * Max Zahn
View author publications You can also search for this author inPubMed Google Scholar * David H Alpers View author publications You can also search for this author inPubMed Google Scholar *
Louis V Avioli View author publications You can also search for this author inPubMed Google Scholar * Patricia Monteleone View author publications You can also search for this author
inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Schwarz, K., Zimmerman, D., Zahn, M. _et al._ 636 MECHANISMS FOR SEX DIFFERENCES
IN ANTACID-INDUCED PHOSPHATE DEPLETION. _Pediatr Res_ 15 (Suppl 4), 546 (1981). https://doi.org/10.1203/00006450-198104001-00649 Download citation * Issue Date: 01 April 1981 * DOI:
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