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ABSTRACT While neutropenia (ANC<1500) related to acute infections in children is well known, natural histroy and appropriate management are unclear. Clinical data on 22 children referred
for neutropenia over a 13 mo. period were reviewed. Twenty patients were age 3 mos.-3 yrs. and 2 were age 11 yrs. ANC was <500/cmm in 18 patients. All patients were febrile at some point
in their illness; the majority (13) had respiratory tract infection. Infectious agents were isolated in 6 patients (S. pneumo. 2, H.flu, 1, E.coli 1, RSV 2). Neutropenia may have been
drug-related in 5 patients (carbamazepine 1, chloramphenicol 2, penicillin 1, ampicillin 1). Bone marrow aspiration, performed in 14 patients, was normal in 7; seven patients demonstrated
maturation arrest. Recovery from neutropenia was documented in 20 patients; one child has remained neutropenic for 12 months and one was lost to follow-up. Ten recovered within 1 wk. of
referral, whereas 10 remained neutropenic from 1 to 6 wks. Time to recovery could not be predicted based on any clinical or laboratory parameters available. These cases of childhood
neutropenia appear to have been infection-related and 20/21 patients recovered. Superimposed bacterial infection did not occur even with ANC<500/cmm; empiric treatment with broad spectrum
antibiotics was not instituted. Bone marrow evaluation, while useful in excluding infiltrative disorders and aplastic anemia, was not predictive of the rate of recovery. ARTICLE PDF AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * SUNY/Downstate Med. Ctr/Kings County Hosp, Brooklyn R Valiaveedan, S Rao, S Miller & A Brown Authors * R Valiaveedan View author publications You
can also search for this author inPubMed Google Scholar * S Rao View author publications You can also search for this author inPubMed Google Scholar * S Miller View author publications You
can also search for this author inPubMed Google Scholar * A Brown View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Valiaveedan, R., Rao, S., Miller, S. _et al._ TRANSIENT NEUTROPENIA OF CHILDHOOD. _Pediatr Res_ 18 (Suppl 4), 250 (1984).
https://doi.org/10.1203/00006450-198404001-00945 Download citation * Issue Date: 01 April 1984 * DOI: https://doi.org/10.1203/00006450-198404001-00945 SHARE THIS ARTICLE Anyone you share the
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