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ABSTRACT Recent reports have shown residual bronchial hyperreactivity in long term survivors of bronchopulmonary dysplasia and Wilson Mikity syndromes. Our aim was to extend these studies to
survivors of uncomplicated RDS. The study group consisted of 7 males and 7 females born between 1974 and 1976. Measurements of static and dynamic lung volumes were made and a methacholine
challenge (MCH) was performed on each child. Expiratory flow rates for the total group were statistically significantly reduced (p < .01). Pulmonary function was significantly lower in
the MCH positive group when compared with the MCH negative group. There was a positive correlation between duration of IPPB and log dose MCH, R = -0.78, p = 0.02. There was no significant
differences between either group for age, sex, height, weight or age at onset of mechanical ventilation. The MCH positive group had received a significantly longer duration of IPPB during
the course of the neonatal respiratory failure. Thus, even in survivors of RDS without major sequelae, there is evidence of residual airway hyperreactivity and abnormal pulmonary function.
We consider this increased airway reactivity and reduced pulmonary function to be one of the risk factors in the development of chronic obstructive pulmonary disease later in life. ARTICLE
PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pulmonary Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada Ian B Maclusky, Joshua Zarfin, Karen Pape &
Henry Levison Authors * Ian B Maclusky View author publications You can also search for this author inPubMed Google Scholar * Joshua Zarfin View author publications You can also search for
this author inPubMed Google Scholar * Karen Pape View author publications You can also search for this author inPubMed Google Scholar * Henry Levison View author publications You can also
search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Maclusky, I., Zarfin, J., Pape, K. _et al._ BRONCHIAL
HYPERREACTIVITY IN LONG TERM SURVIVORS OF THE NEONATAL RESPIRATORY DISTRESS SYNDROME (RDS). _Pediatr Res_ 18 (Suppl 4), 395 (1984). https://doi.org/10.1203/00006450-198404001-01816 Download
citation * Issue Date: 01 April 1984 * DOI: https://doi.org/10.1203/00006450-198404001-01816 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:
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