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ABSTRACT Successful treatment of PP by daily subcutaneous (SC) administration of the LH-RH agonist D-Trp-6-LH-RH (Trp6) was reported (Kauli et al., ESPE 1983). After demonstration of its
efficiency and innocuity in dogs, a long acting preparation designed for releasing continuously 100 μg Trp6 per 24 h, was given intramuscularly to 3 boys and 3 girls with PP, aged 3 to 8
years. 3 mg Trp6 were injected every 28 days, cyproterone acetate being associated during the first week. In boys testosterone levels (ng/ml) decreased from 2.2-5 to 0.1-0.2 within 2 months.
Testis volume was unaffected in 1, decreased slighty in 2. In girls estradiol levels (pg/ml) decreased from 40-100 to 0-40 within 2 months and in a menstruating girl genital bleeding
desappeared after 1 month. Breast enlargement was reduced in all. In all children, the gonadotropin responses to LH-RH were suppressed and the inhibition of gonadal secretion persisted after
6 months of treatment. The data demonstrate the ability of long acting Trp6 to suppress gonadal secretion by a monthly injection in children with PP. ARTICLE PDF AUTHOR INFORMATION AUTHORS
AND AFFILIATIONS * Fondation de Recherche en Hormonologie and Hopital Saint Vincent de Paul, Paris, France M Roger, J L Chaussain, F Raynaud, J E Toublanc, P Canlorbe, J C Job & A V
Schally * Veterans Administration Hospital, New Orleans, Louisianna M Roger, J L Chaussain, F Raynaud, J E Toublanc, P Canlorbe, J C Job & A V Schally Authors * M Roger View author
publications You can also search for this author inPubMed Google Scholar * J L Chaussain View author publications You can also search for this author inPubMed Google Scholar * F Raynaud View
author publications You can also search for this author inPubMed Google Scholar * J E Toublanc View author publications You can also search for this author inPubMed Google Scholar * P
Canlorbe View author publications You can also search for this author inPubMed Google Scholar * J C Job View author publications You can also search for this author inPubMed Google Scholar *
A V Schally View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Roger,
M., Chaussain, J., Raynaud, F. _et al._ Treatment of male and female precocious puberty (PP) by monthly injections of a continuous release preparation of D-Trp-6-LH-RH. _Pediatr Res_ 18,
1209 (1984). https://doi.org/10.1203/00006450-198411000-00053 Download citation * Issue Date: November 1984 * DOI: https://doi.org/10.1203/00006450-198411000-00053 SHARE THIS ARTICLE Anyone
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