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ABSTRACT Published guidelines for gentamicin doses based on weight may not be appropriate for low birth weight infants. Utilizing first order pharmacokinetics, a computer assisted program
was used based on birth weight and known peak (P) and trough (T) levels when a standard dose of gentamicin of 2.5 mg/kg q 12 hr IM was given. The dose of IM gentamicin and the interval of
administration was then calculated by the program. The dose of gentamicin was so accurate that subsequent gentamicin levels were maintained at less than 8mcg/ml (P) and less than 2mcg/ml (T)
thereby reducing the chance for renal or oto-toxicity. Sub-theraputic levels of gentamicin did not occur. Our data for IM gentamicin confirm work by Edgren (Pediat. Res 16:A-273, 1982) for
IV gentamicin in low birth weight infants. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics and Hospital Pharmacy, Medical College of Virginia,
Children's Medical Center, Richmond, Virginia M Albert, S Pedigo, S Ternullo, A Napolitano & B Kirkpatrick Authors * M Albert View author publications You can also search for this
author inPubMed Google Scholar * S Pedigo View author publications You can also search for this author inPubMed Google Scholar * S Ternullo View author publications You can also search for
this author inPubMed Google Scholar * A Napolitano View author publications You can also search for this author inPubMed Google Scholar * B Kirkpatrick View author publications You can also
search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Albert, M., Pedigo, S., Ternullo, S. _et al._ COMPUTER
ASSISTED DOSAGE FOR INTRA-MUSCULAR GENTAMICIN FOR INFANTS LESS THAN 1500 GRAMS. _Pediatr Res_ 18 (Suppl 4), 148 (1984). https://doi.org/10.1203/00006450-198404001-00332 Download citation *
Issue Date: 01 April 1984 * DOI: https://doi.org/10.1203/00006450-198404001-00332 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable
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