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ABSTRACT ABSTRACT: The aim of the present study was to create clearly documented immediate-type allergy to food protein in the intestine of rats and to study some pathophysiological
phenomena induced by challenge with the allergen. To achieve this, rats were sensitized with ovalbumin. A passive cutaneous anaphylaxis reaction to ovalbumin was negative in all controls and
positive in all test animals when _Bordetella pertussis_ was used as adjuvant. Sixty minutes after an intravenous injection of 125I-human serum albumin and 45 min after an ovalbumin
challenge, given by gavage, the rats were sacrificed. The intestine was removed and sections taken for morphologic studies. The remainder was rinsed, opened, cut into measured segments,
weighed, and the radioactivity was measured. Disaccharidases, alkaline phosphatase, and protein were estimated in homogenates of epithelium. Results in both control and test animals showed
that radioactivity decreased as one moved distally along the intestine. However, radioactivity was significantly higher (_p_ < 0.01) in the intestine of test animals than in controls.
Radioactivity in liver, kidney, spleen, and lungs was identical in test and control animals. There was significant reduction in levels of alkaline phosphatase (p varied from < 0.05 to
< 0.001), maltase (_p_ < 0.05), and sucrase (_p_ < 0.05 to < 0.01). Lactase activity in contrast was significantly raised (_p_ < 0.05). There was no change in intestinal
morphology or in the intestinal mast cell count. SIMILAR CONTENT BEING VIEWED BY OTHERS PEACH EXTRACT INDUCES SYSTEMIC AND LOCAL IMMUNE RESPONSES IN AN EXPERIMENTAL FOOD ALLERGY MODEL
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ANAPHYLAXIS IN MICE Article 23 June 2020 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Gastrointestinal Research Laboratories, Shaare Zedek Medical Center, Jerusalem, Israel
Serem Freier, Maya Eran & Robert Goldstein Authors * Serem Freier View author publications You can also search for this author inPubMed Google Scholar * Maya Eran View author
publications You can also search for this author inPubMed Google Scholar * Robert Goldstein View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Freier, S., Eran, M. & Goldstein, R. The Effect of Immediate-Type Gastrointestinal Allergic Reactions on Brush
Border Enzymes and Gut Morphology in the Rat. _Pediatr Res_ 19, 456–459 (1985). https://doi.org/10.1203/00006450-198505000-00010 Download citation * Received: 12 March 1984 * Accepted: 31
December 1984 * Issue Date: May 1985 * DOI: https://doi.org/10.1203/00006450-198505000-00010 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:
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