Impairment of mucosal hyperplasia following massive small bowel resection by essential fatty acid (efa) deficiency

Impairment of mucosal hyperplasia following massive small bowel resection by essential fatty acid (efa) deficiency

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ABSTRACT Previous studies have shown that dietary long chain triglycerides stimulate mucosal hyperplasia following massive small bowel resection. In these studies, however, mucosal hyperplasia in “control” animals may have actually been inhibited by short term EFA deficiency. To evaluate this possibility 24 Sprague-Dawley rats were subjected to 60% proximal jejunoileal resection and subsequently pair-fed isocaloric diets containing either linoleic (control) or palmitic (EFA deficient) acid (5% fat by weight). Two weeks postoperatively, mucosal protein (mg/cm bowel + SEM) was determined in the remaining bowel:: Mucosal protein levels were decreased in EFA deficient resected animals in all segments in remaining bowel (p<.05). Mucosal DNA levels paralleled these changes. A subsequent study demonstrated rapid reversal of impairment of mucosal hyperplasia following reinstitution of EFA containing diets. Hepatic triene:tetraene ratios confirmed EFA deficiency in the palmitic acid group. EFA deficiency impaired mucosal adaptation following resection. This effect was reversible, and may explain stimulatory effects of long chain triglycerides on mucosal hyperplasia. SIMILAR CONTENT BEING VIEWED BY OTHERS THE EFFECT OF PRE-RESECTION OBESITY ON POST-RESECTION BODY COMPOSITION AFTER 75% SMALL BOWEL RESECTION IN RATS Article Open access 21 June 2021 COMPARISON OF THREE DIFFERENT ANASTOMOTIC METHODS OF SLEEVE GASTRECTOMY WITH TRANSIT BIPARTITION USING AN OBESE RODENT MODEL Article Open access 01 December 2023 LIPID ABSORPTION AND OVERALL INTESTINAL LYMPHATIC TRANSPORT ARE IMPAIRED FOLLOWING PARTIAL SMALL BOWEL RESECTION IN MICE Article Open access 07 July 2022 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University of Nebraska Medical Center and Swanson Center for Nutrition, Inc., Omaha, Nebraska, USA J A Vanderhoof & M H Hart Authors * J A Vanderhoof View author publications You can also search for this author inPubMed Google Scholar * M H Hart View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Vanderhoof, J., Hart, M. IMPAIRMENT OF MUCOSAL HYPERPLASIA FOLLOWING MASSIVE SMALL BOWEL RESECTION BY ESSENTIAL FATTY ACID (EFA) DEFICIENCY. _Pediatr Res_ 20, 690 (1986). https://doi.org/10.1203/00006450-198607000-00028 Download citation * Issue Date: 01 July 1986 * DOI: https://doi.org/10.1203/00006450-198607000-00028 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT Previous studies have shown that dietary long chain triglycerides stimulate mucosal hyperplasia following massive small bowel resection. In these studies, however, mucosal


hyperplasia in “control” animals may have actually been inhibited by short term EFA deficiency. To evaluate this possibility 24 Sprague-Dawley rats were subjected to 60% proximal jejunoileal


resection and subsequently pair-fed isocaloric diets containing either linoleic (control) or palmitic (EFA deficient) acid (5% fat by weight). Two weeks postoperatively, mucosal protein


(mg/cm bowel + SEM) was determined in the remaining bowel:: Mucosal protein levels were decreased in EFA deficient resected animals in all segments in remaining bowel (p<.05). Mucosal DNA


levels paralleled these changes. A subsequent study demonstrated rapid reversal of impairment of mucosal hyperplasia following reinstitution of EFA containing diets. Hepatic triene:tetraene


ratios confirmed EFA deficiency in the palmitic acid group. EFA deficiency impaired mucosal adaptation following resection. This effect was reversible, and may explain stimulatory effects


of long chain triglycerides on mucosal hyperplasia. SIMILAR CONTENT BEING VIEWED BY OTHERS THE EFFECT OF PRE-RESECTION OBESITY ON POST-RESECTION BODY COMPOSITION AFTER 75% SMALL BOWEL


RESECTION IN RATS Article Open access 21 June 2021 COMPARISON OF THREE DIFFERENT ANASTOMOTIC METHODS OF SLEEVE GASTRECTOMY WITH TRANSIT BIPARTITION USING AN OBESE RODENT MODEL Article Open


access 01 December 2023 LIPID ABSORPTION AND OVERALL INTESTINAL LYMPHATIC TRANSPORT ARE IMPAIRED FOLLOWING PARTIAL SMALL BOWEL RESECTION IN MICE Article Open access 07 July 2022 ARTICLE PDF


AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University of Nebraska Medical Center and Swanson Center for Nutrition, Inc., Omaha, Nebraska, USA J A Vanderhoof & M H Hart Authors * J A


Vanderhoof View author publications You can also search for this author inPubMed Google Scholar * M H Hart View author publications You can also search for this author inPubMed Google


Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Vanderhoof, J., Hart, M. IMPAIRMENT OF MUCOSAL HYPERPLASIA FOLLOWING MASSIVE SMALL BOWEL


RESECTION BY ESSENTIAL FATTY ACID (EFA) DEFICIENCY. _Pediatr Res_ 20, 690 (1986). https://doi.org/10.1203/00006450-198607000-00028 Download citation * Issue Date: 01 July 1986 * DOI:


https://doi.org/10.1203/00006450-198607000-00028 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is


not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative