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ABSTRACT Previous studies have shown that dietary long chain triglycerides stimulate mucosal hyperplasia following massive small bowel resection. In these studies, however, mucosal
hyperplasia in “control” animals may have actually been inhibited by short term EFA deficiency. To evaluate this possibility 24 Sprague-Dawley rats were subjected to 60% proximal jejunoileal
resection and subsequently pair-fed isocaloric diets containing either linoleic (control) or palmitic (EFA deficient) acid (5% fat by weight). Two weeks postoperatively, mucosal protein
(mg/cm bowel + SEM) was determined in the remaining bowel:: Mucosal protein levels were decreased in EFA deficient resected animals in all segments in remaining bowel (p<.05). Mucosal DNA
levels paralleled these changes. A subsequent study demonstrated rapid reversal of impairment of mucosal hyperplasia following reinstitution of EFA containing diets. Hepatic triene:tetraene
ratios confirmed EFA deficiency in the palmitic acid group. EFA deficiency impaired mucosal adaptation following resection. This effect was reversible, and may explain stimulatory effects
of long chain triglycerides on mucosal hyperplasia. SIMILAR CONTENT BEING VIEWED BY OTHERS THE EFFECT OF PRE-RESECTION OBESITY ON POST-RESECTION BODY COMPOSITION AFTER 75% SMALL BOWEL
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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University of Nebraska Medical Center and Swanson Center for Nutrition, Inc., Omaha, Nebraska, USA J A Vanderhoof & M H Hart Authors * J A
Vanderhoof View author publications You can also search for this author inPubMed Google Scholar * M H Hart View author publications You can also search for this author inPubMed Google
Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Vanderhoof, J., Hart, M. IMPAIRMENT OF MUCOSAL HYPERPLASIA FOLLOWING MASSIVE SMALL BOWEL
RESECTION BY ESSENTIAL FATTY ACID (EFA) DEFICIENCY. _Pediatr Res_ 20, 690 (1986). https://doi.org/10.1203/00006450-198607000-00028 Download citation * Issue Date: 01 July 1986 * DOI:
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