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ABSTRACT TNF is a cytokine released by activated monocytes exerting a number of reactions that may occur during HD (fever, neutropenia, monocytopenia, vascular endothelial lesions). We
measured serum levels of TNF in 6 adolescents aged 14-21 years undergoing regular HD 5 min before and 15 min after start of the procedure with cuprophane membranes. Before HD TNF could not
be detected in measurable amounts. In contrast, 5 of 6 sera taken after start of the HD session we found significant amounts of TNF (1045-7000 pg/ml serum). Our results suggest that TNF is
released by HD. Therefore the above mentioned side effects of HD may be related to the action of TNF. The high TNF levels may also contribute to the development of autoantibodies or the
persistance of cytotoxic antibodies in HD pts. Supported by BMFT, Bonn, FRG, PTB#03 8397 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University Children's Hospitals of
Munich, FRG R Eife & B Sigmund * University Children's Hospitals of Heidelberg, FRG D E Müller-wiefel & O Mehls * Dept. Virology, Weizmann Inst. of Science, Rehovot, Israel H
Engelmann, H Holtmann & D Wallach Authors * R Eife View author publications You can also search for this author inPubMed Google Scholar * D E Müller-wiefel View author publications You
can also search for this author inPubMed Google Scholar * B Sigmund View author publications You can also search for this author inPubMed Google Scholar * O Mehls View author publications
You can also search for this author inPubMed Google Scholar * H Engelmann View author publications You can also search for this author inPubMed Google Scholar * H Holtmann View author
publications You can also search for this author inPubMed Google Scholar * D Wallach View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Eife, R., Müller-wiefel, D., Sigmund, B. _et al._ ELEVATED LEVELS OF TUMOR NECROSIS FACTOR (TNF) IN ADOLESCENTS ON
HEMODIALYSIS (HD). _Pediatr Res_ 22, 224 (1987). https://doi.org/10.1203/00006450-198708000-00065 Download citation * Issue Date: 01 August 1987 * DOI:
https://doi.org/10.1203/00006450-198708000-00065 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is
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