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ABSTRACT The objectives of the ECS are to determine:- 1. the prevalance of HIV infection in infanats born to positive mothers; 2. the risk factors influencing transmission to infants; 3. the
natural history of HIV infection in infants; 4. precursors of AIDS/ARC onset in infected infants. Seven centres are participating; Padua, Edinburgh, Berlin, Madrid, Valencia and Amsterdam.
Seropositive women are identified in the antenatal period and the paediatrician is notified. Children are investigated in the newborn period and at 3-monthly intervals. By 31/3/88 204
children, mean birth wt. 2800g mean gest. age 38wks, had been enrolled into the study. 85% of mothers were IV drug abusers; 25% of babies had drug withdrwal symptoms. 122 children have been
followed for at least 6 months and 89 for over 1 year. The median age at last visit was 12 months. 10 children had developed AIDS or ARC (all by 9 months) 5 had died of opportunistic
infections; 3 premature infants died in the neonatal period. 18 infants had nonspecific signs or symptoms. The majority 173/204 were clinically normal when last seen. No cases of AIDS
dysmorphic syndrome were described. 9/65 (14%) children over 15 months remain antibody positive. 4 other children died of AIDS/ARC who would have been over 15 months had they survived.
Several children have lost antibody despite being virus and/or antigen positive. At present the numbers are too small for meaningful estimates of risk factors in relation to infection to be
calculated. There have been no side effects with any immunisations. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute of Child Health, Dept of Paediatric Epidemiology, WC1N
1EH, London, England Yvonne Senturia Authors * Yvonne Senturia View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Senturia, Y. 2. HIV IN PAEDIATRICS-THE EUROPEAN COLLABORATIVE STUDY (ECS). _Pediatr Res_ 24, 653 (1988).
https://doi.org/10.1203/00006450-198811000-00024 Download citation * Issue Date: 01 November 1988 * DOI: https://doi.org/10.1203/00006450-198811000-00024 SHARE THIS ARTICLE Anyone you share
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