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ABSTRACT Studies on rickets of prematurity have focussed on the calcium, phosphorus and vitamin D requirements of infants, but skeletal development may be stressed if magnesium is deficient.
The present study examines the effects of increasing calcium and phosphorus on magnesium retention. Five groups of very low birthweight infants were fed milk with magnesium content 5 mg/100
ml. Calcium and phosphorus were supplemented to the following concentrations (Ca:P mg/100 ml); Group A 44:33, Group B 84:33, Group C 125:33, Croup D 125:50 and Group E 125:64. Three-day
balance studies were performed starting at 10, 20, 30 and 40 days. Increasing both calcium and phosphorus contents decreased magnesium retention to lower than in utero accretion rates.
Doubling magnesium content of milk to 10 mg/100 ml did not prevent negative magnesium balance in very preterm infants at 10 days, although magnesium retention doubled in older (20 days) or
more mature (32-34 weeks gestation) infants. We conclude that increasing calcium and phosphorus content of milks to prevent rickets of prematurity could produce a magnesium deficiency in
very low birthweight infants, with possible compromise of bone formation. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Child Life and Health, and the Medical
Computing and Statistics Unit, University of Edinburgh, Scotland Ian A Laing, Merete M Giles, Robert A Elton, James B Robina, Margaret B Sanderson & Robert Hume Authors * Ian A Laing
View author publications You can also search for this author inPubMed Google Scholar * Merete M Giles View author publications You can also search for this author inPubMed Google Scholar *
Robert A Elton View author publications You can also search for this author inPubMed Google Scholar * James B Robina View author publications You can also search for this author inPubMed
Google Scholar * Margaret B Sanderson View author publications You can also search for this author inPubMed Google Scholar * Robert Hume View author publications You can also search for this
author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Laing, I., Giles, M., Elton, R. _et al._ MAGNESIUM METABOLISM IN PRETERM
INFANTS: THE EFFECT OF CALCIUM AND PHOSPHORUS. _Pediatr Res_ 26, 507 (1989). https://doi.org/10.1203/00006450-198911000-00049 Download citation * Issue Date: 01 November 1989 * DOI:
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