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ABSTRACT To evaluate the effects of congenital dialphragmatic hemia (CDH) and pulmonary hypoplasia on subsequent lung development, we performed lung Xenon 133 ventilation and M.A.A. - Tc 99m
perfusion scintigraphies (LVPS) in 16 patients (pts) 2-3 months of age who had had surgical repair of a left CDH within the first 12 hours of life. 10 of these 16 pts were reevaluated at
1-2 years and again at 5-6 years in 6 of them. On the initial lung scintigraphies, ventilation (V) to the hernia side was decreased in 8/16 pts and Δ[VR-VL] averaged 12.6 ± 13.7. In 9/16
pts, there was a trapping of Xenon 133 at the left lung base. Perfusion (P) to the hernia side was decreased in 11/16 pts and Δ[PR-PL] averaged 26.2 ± 23.2. Correlation between V and P was
good : r = 0.70, p < 0.01. After 1 year, V to the hernia side became normal except in 2/10 pts (ΔV = 5.2 ± 4.9), but P to the hernia side remained low in 9/10 pts (ΔP = 21.2 ± 7.9). After
5 years, V was normal in all of the 6 pts studied (ΔV = 2.6 ± 3.1); however P to the hernia side was still reduced in 5/6 pts (ΔP = 18.6 ± 5.4). These results show a progressive inprovemsnt
and normalization of V and a persisting reduction of P to the lung of the hernia side, suggesting a primary vascular pulmonary hypoplasia in CDH. LVPS is a unique ncn invasive method that
provides quantitative and qualitative informations on P and V, which are very helpful in the follow-up of repaired CDH, during the first years of life when physiologic studies are most
difficult to obtain. ARTICLE PDF Authors * J L Demarquez View author publications You can also search for this author inPubMed Google Scholar * B Lambert View author publications You can
also search for this author inPubMed Google Scholar * T Lamireau View author publications You can also search for this author inPubMed Google Scholar * R I Galperine View author publications
You can also search for this author inPubMed Google Scholar * A J Brendel View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS
Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Demarquez, J., Lambert, B., Lamireau, T. _et al._ LUNG VENTILATION AND PERFUSION SCINTIGRAPHY IN THE FOLLOW-UP OF REPAIRED
CONGENITAL DIAPHRAGMATIC HERNIA. _Pediatr Res_ 26, 508 (1989). https://doi.org/10.1203/00006450-198911000-00056 Download citation * Issue Date: 01 November 1989 * DOI:
https://doi.org/10.1203/00006450-198911000-00056 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is
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