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Sensorineural hearing loss is one of the major sequelae of neonatal hyperbilirubinemia. Retrocochlear sites of lesions due to kernicterus are related to significant abnormalities in the wave
latencies, interwave intervals, and amplitudes of the auditory brainstem response. In the present study, changes in the expression of the calcium binding proteins (CBP) parvalbumin and
calbindin-D28k have been examined in the homozygous recessive jaundiced (jj) Gunn rat by light microscopic immunohistochemistry at 15-18 days postnatally. The density of immunoreactive
staining for both CBPs was reduced in the cochlear nuclei and the superior olivary complex, particularly the superior paraolivary and medial superior olivary nuclei, in comparison to
age-matched heterozygous (Nj) control rats. At both sites, the extent of the reduction in immunoreactivity was related to the severity of the clinical symptoms. By contrast, immunoreactive
staining in other brainstem auditory(e.g., dorsal and ventral nuclei of the lateral lemniscus, inferior colliculus, medial geniculate body) and neighboring non-auditory structures was
similar in jaundiced and control rats. The developmental retardation of CBPs coincides with the period of synaptic refinement in the auditory brainstem, and the inability to buffer
intracellular calcium effectively may lead to bilirubin-induced neuronal cell death, possibly by inhibition of Ca2+/calmodulin-dependent kinase II activity. Supported by NIH NIDCD R01
DC00369 (SMS) and MERIT Award EY02191 (RFS). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Otolaryngology, Neurology, Pediatrics, Physiology and Anatomy, Medical College of Virginia,
Virginia Commonwealth University, Richmond, VA, USA Justin J. G. Broughton, David L. Galiani, Steven M. Shapiro & Robert F. Spencer Authors * Justin J. G. Broughton View author
publications You can also search for this author inPubMed Google Scholar * David L. Galiani View author publications You can also search for this author inPubMed Google Scholar * Steven M.
Shapiro View author publications You can also search for this author inPubMed Google Scholar * Robert F. Spencer View author publications You can also search for this author inPubMed Google
Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Broughton, J., Galiani, D., Shapiro, S. _et al._ Expression of Calcium Binding Proteins in the
Auditory Brainstem Pathway of the Jaundiced Gunn Rat † 829. _Pediatr Res_ 41 (Suppl 4), 141 (1997). https://doi.org/10.1203/00006450-199704001-00849 Download citation * Issue Date: 01 April
1997 * DOI: https://doi.org/10.1203/00006450-199704001-00849 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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