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This study was performed to test the hypothesis that the levels of neurotrophic growth factors, bFGF and TGF-βlin CSF are increased in children with bacterial meningitis, and also related
with their outcome. The levels of bFGF and TGF-β1 were measured by a sandwich enzyme immunoassay in children aged below 15 years, with bacterial meningitis (BM) (n=18), aseptic meningitis
(AM) (n=12), encephalitis (EN) (n=8), and control (CN) children (n=18). At a mean duration of follow-up of 17 months was performed to determine their neurodevelopmental sequelae. Both CSF
bFGF and TGF-β1 were significantly higher in children with BM than those with AM, EN, or CN. There was no significant difference in CSF bFGF or TGF-β1 between patients with AM, EN and CN.
Except for two patients with acute fatality, the CSF bFGF decreased significantly after 24-48 hours of antibiotic treatment(p<0.0005) in patients with BM. All 3 patients who had CSF bFGF
above 20 pg/ml, died. Patients of BM with major sequelae had significantly higher levels of CSF bFGF than those without (p<0.05); this difference between the groups was not seen in
TGF-β1. Our results demonstrated that CSF bFGF and TGF-β1 are elevated during acute bacterial meningitis, and bFGF is associated with the severity of the disease, especially fatality. The
production and release of neurotrophic factors appear to play an important role in the pathophysiology of bacterial meningitis in children.Table AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *
Depts of Pediatrics, National Cheng Kung University Medical Center, Tainan, Taiwan C C Huang, Y C Chang & T F Yeh * Depts of Pathology, National Cheng Kung University Medical Center,
Tainan, Taiwan N H Chow * Public Health, National Cheng Kung University Medical Center, Tainan, Taiwan S T Wang Authors * C C Huang View author publications You can also search for this
author inPubMed Google Scholar * Y C Chang View author publications You can also search for this author inPubMed Google Scholar * T F Yeh View author publications You can also search for
this author inPubMed Google Scholar * N H Chow View author publications You can also search for this author inPubMed Google Scholar * S T Wang View author publications You can also search
for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Huang, C., Chang, Y., Yeh, T. _et al._ Levels of Basic Fibroblast
Growth Factor (bFGF) and Transforming Growth Factor-betal (TGF-β1) in Cerebrospinal Fluid (CSF) and the Severity of Bacterial Meningitis in Children † 1732. _Pediatr Res_ 41 (Suppl 4), 291
(1997). https://doi.org/10.1203/00006450-199704001-01751 Download citation * Issue Date: 01 April 1997 * DOI: https://doi.org/10.1203/00006450-199704001-01751 SHARE THIS ARTICLE Anyone you
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