Play all audios:
Low bone mineral density (BMD) has been demonstrated in adults and children with IH. The attainment of peak bone mass and eventual adult bone mass appear to be greatly determined by several
genotypic factors. It appears that IH may also be linked to yet unidentified genotypic determinants. Therefore, we decided to evaluate the BMD status in asymptomatic mothers of children with
diagnosed IH. BMD was measured by dual x ray absorptiometry (Lunar Corp.,Madison, WI) at lumbar spine (L2-L4) and femur (neck and Ward's triangle) in 22 IH children with a mean age of
9.0±3.8 yr, and a urinary calcium of 6.0±2.9 mg/kg/24 hr. Simultaneously, we evaluated the BMD in their corresponding 21 asymptomatic premenopausal mothers with a mean age of 39.7±5.0 yr.
Values are expressed as standard deviation scores compared to age and gender matched controls (Z scores) or young adults(T scores). Osteopenia is defined as a score greater than -1.
Osteopenia was observed in 38% of IH children and in 33% of their mothers. Osteopenic or normal BMD values were concordant in 12/21 (57%) of all mother-child pairs. Urinary pyridinoline,
deoxypyridinoline, or N-telopeptide of collagen Type I were elevated in 4/7 mothers with osteopenia (57%). Hypercalciuria was detected in 14/20 mothers (70%), and was present in 6/7(86%) of
those displaying osteopenia. No correlation was obtained between urinary calcium excretion and BMD. Our results demonstrate osteopenia in a large proportion of children with IH. Furthermore,
unsuspected hypercalciuria, osteopenia, and biochemical evidence of excessive bone resorption, were found in a substantial number of their otherwise healthy mothers.
In summary, the observed decreased BMD in adults with IH may start early in life, could be determined by genotypic factors, and might represent an important risk factor for osteoporosis
later in life. Screening for reduced BMD should be considered in asymptomatic mothers of children with IH. Table
Anyone you share the following link with will be able to read this content: