ABSTRACT Plasma aldosterone/renin ratio (ARR) is a useful method for primary aldosteronism (PA) screening. However some confounders, such as medications and dietary, affect plasma renin and

aldosterone levels, resulting in false-negative or -positive plasma ARR. This study investigated the association between postmenopausal osteoporosis (PMO) and plasma ARR. Bone mineral

density (BMD) was measured by dual-energy X-ray-absorptiometry (DXA) in 324 normotensive postmenopausal women. Based on clinical characteristics and BMD, 186 and 96 subjects were diagnosed

as PMO and osteopenia respectively, and the remaining 42 subjects were grouped as normal BMD. Plasma aldosterone concentration (PAC), plasma renin concentration (PRC), parathyroid hormone

women with normal BMD and osteopenia, respectively. Using ARR ≥ 37.0 pg/μU as the cutoff for positive screening, more false-positive was found in the PMO group when compared to the normal

BMD group (24 vs. 2%) and osteopenia group (24 vs. 7%), respectively. PAC was negatively associated with lumbar spine BMD T-score (_r_ = −0.239, _p_ < 0.001), femur neck BMD T-score (_r_ 

= −0.234, _p_ < 0.001) and total hip BMD T-score (_r_ = −0.228, _p_ < 0.001). PTH was positively associated with PAC (_r_ = 0.119, _p_ < 0.05) and ARR (_r_ = 0.136, _p_ < 0.05).

PAC and ARR are elevated in women with PMO, which might increase the risk of false-positive for case detection of PA. Access through your institution Buy or subscribe This is a preview of

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Osteoporos Int. 2013;24:2801–7. Article  PubMed  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The sources of funding include the National Natural Science Foundation of China

(81370954, 81670785) to Qifu Li; and the Fundamental Science & Advanced Technology Research of Chongqing (Major Project, cstc2015jcyjBX0096) to Qifu Li. Chongqing Science and Technology

Committee Innovation Project (Technology Development and Application of Precision Medicine, cstc2016shms-ztzx1003) to Qifu Li. MEMBERSHIP OF THE CHONGQING PRIMARY ALDOSTERONISM

STUDY(CONPASS) GROUP Qifu Li, MD, PhD; Ying Song, MD; Shumin Yang, MD, PhD; Wenwen He, MD; Mei Mei, MD, PhD; Jinbo Hu, PhD; Suxin Luo, MD, PhD; Kangla Liao, MD; Yao Zhang, MD, PhD; Yunfeng

He, PhD; Yihong He; Ming Xiao, PhD; and Bin Peng, PhD. AUTHOR INFORMATION Author notes * These authors contributed equally: Xiaoyu Shu, Mei Mei. AUTHORS AND AFFILIATIONS * Department of

Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Xiaoyu Shu, Mei Mei, Linqiang Ma, Zhihong Wang, Shumin Yang, Jinbo Hu, Ying Song, Wenwen He, 

Ting Luo, Qingfeng Cheng, Yue Wang, Qianna Zhen & Qifu Li * Department of Endocrinology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China Xiaoyu Shu Authors * Xiaoyu

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STUDY(CONPASS) GROUP CORRESPONDING AUTHOR Correspondence to Qifu Li. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare that they have no conflict of interest. ADDITIONAL

INFORMATION Membership of the CONPASS group is provided in the Acknowledgements. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Shu, X., Mei, M., Ma, L.

_et al._ Postmenopausal osteoporosis is associated with elevated aldosterone/renin ratio. _J Hum Hypertens_ 32, 524–530 (2018). https://doi.org/10.1038/s41371-018-0069-7 Download citation *

Received: 02 November 2017 * Revised: 18 March 2018 * Accepted: 16 April 2018 * Published: 22 May 2018 * Issue Date: July 2018 * DOI: https://doi.org/10.1038/s41371-018-0069-7 SHARE THIS

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