ABSTRACT OBJECTIVE Assess if maternal betamethasone administration at 34–35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. STUDY DESIGN Nested, observational cohort

in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 340–356 weeks gestation before 72 h (aEEG 1) and at 5–7

days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were

border voltage, span, and discontinuity. RESULTS 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had

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AUTONOMIC CARDIOVASCULAR CONTROL IN FOETAL-GROWTH-RESTRICTED PRETERM INFANTS Article Open access 06 September 2024 IMPACT OF PRENATAL OPIOIDS ON CARDIAC AND AUTONOMIC DEVELOPMENT: SYSTEMATIC

REVIEW AND META-ANALYSIS Article 29 July 2022 VENTILATORY CONTROL INSTABILITY AS A PREDICTOR OF PERSISTENT PERIODIC BREATHING IN PRETERM INFANTS Article 29 October 2021 DATA AVAILABILITY

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preterm infants. Sci Rep. 2019;9:4859. Article  PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS The National Institutes of Health, the _Eunice Kennedy Shriver_

National Institute of Child Health and Human Development (NICHD), the National Heart, Lung, and Blood Institute, and the National Center for Advancing Translational Sciences provided grant

support for the Maternal-Fetal Medicine Units Network’s ALPS trial and the Neonatal Research Network’s aEEG secondary study. NICHD staff provided input into the study design, conduct,

analysis, and manuscript drafting; NCATS cooperative agreements provided infrastructure support to the NRN. While NICHD staff had input into the study design, conduct, analysis, and

manuscript drafting, the comments and views of the authors do not necessarily represent the views of NICHD, the National Institutes of Health, the Department of Health and Human Services, or

the U.S. Government. Data collected at participating sites of the NICHD Neonatal Research Network (NRN) were transmitted to RTI International, the data coordinating center (DCC) for the

network, which stored, managed and analyzed the data included in this study. On behalf of the NRN, RTI International had full access to all the data in the study and take responsibility for

the integrity of the data and accuracy of the data analysis. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National

Institutes of Health. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study. The investigators below, in addition to

those listed as authors, participated in this study. FUNDING Financial support was provided by NICHD Cooperative Multicenter Neonatal Research Network, UG1HD027904 and the NICHD Cooperative

Multicenter Maternal-Fetal Medicine Units Network, U10HD036801. ClinicalTrials.gov ID ALPS: NCT01222247. AUTHOR INFORMATION Author notes * Deceased: Elizabeth A. Thom. AUTHORS AND

AFFILIATIONS * Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA Abbot R. Laptook, William Oh & Angelita M. Hensman * Department of Pediatrics,

University of Texas Southwestern Medical Center, Dallas, TX, USA Lina Chalak * Department of Pediatrics, Wayne State University, Detroit, MI, USA Athina Pappas & Seetha Shankaran *

Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children’s Hospital, Palo Alto, CA, USA Alexis Davis 

& Krisa P. Van Meurs * Department of Pediatrics, Nationwide Children’s Hospital, The Ohio State College of Medicine, Abigail Wexner Research Institute at Nationwide Children’s Hospital,

Columbus, OH, USA Pablo J. Sanchez * Neonatology, Wellington Medical Center, Boca Raton, FL, USA Ross Sommers * Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine,

Women and Infants Hospital, Brown University, Providence, RI, USA Dwight J. Rouse * Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle, NC, USA Scott

McDonald * Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA Abhik Das * Department of Pediatrics, Duke University, Durham, NC, USA Ronald N.

Goldberg * Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA Namasivayam Ambalavanan * Department of Obstetrics and Gynecology, Columbia University Irving

Medical Center, New York, NY, USA Cynthia Gyamfi-Bannerman * Department of Biostatistics and Bioinformatics, George Washington University, Washington, DC, USA Elizabeth A. Thom * Department

of Global and Community Health, George Mason University, Fairfax, VA, USA Rosemary D. Higgins * Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA

Abbot R. Laptook, William Oh & Angelita M. Hensman * Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA Lina Chalak * Department of Pediatrics,

Wayne State University, Detroit, MI, USA Athina Pappas & Seetha Shankaran * Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of

Medicine and Lucile Packard Children’s Hospital, Palo Alto, CA, USA Alexis Davis & Krisa P. Van Meurs * Department of Pediatrics, Nationwide Children’s Hospital, The Ohio State College

of Medicine, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA Pablo J. Sanchez * Social, Statistical and Environmental Sciences Unit, RTI International,

Research Triangle, NC, USA Scott McDonald * Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA Abhik Das * Department of Pediatrics, Duke University,

Durham, NC, USA Ronald N. Goldberg * Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA Namasivayam Ambalavanan * Department of Global and Community Health,

George Mason University, Fairfax, VA, USA Rosemary D. Higgins * Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Women and Infants Hospital, Brown University,

Providence, RI, USA Dwight J. Rouse * Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA Cynthia Gyamfi-Bannerman * Department of

Biostatistics and Bioinformatics, George Washington University, Washington, DC, USA Elizabeth A. Thom Authors * Abbot R. Laptook View author publications You can also search for this author

inPubMed Google Scholar * Lina Chalak View author publications You can also search for this author inPubMed Google Scholar * Athina Pappas View author publications You can also search for

this author inPubMed Google Scholar * Alexis Davis View author publications You can also search for this author inPubMed Google Scholar * Pablo J. Sanchez View author publications You can

also search for this author inPubMed Google Scholar * Krisa P. Van Meurs View author publications You can also search for this author inPubMed Google Scholar * William Oh View author

publications You can also search for this author inPubMed Google Scholar * Ross Sommers View author publications You can also search for this author inPubMed Google Scholar * Seetha

Shankaran View author publications You can also search for this author inPubMed Google Scholar * Angelita M. Hensman View author publications You can also search for this author inPubMed 

Google Scholar * Dwight J. Rouse View author publications You can also search for this author inPubMed Google Scholar * Scott McDonald View author publications You can also search for this

author inPubMed Google Scholar * Abhik Das View author publications You can also search for this author inPubMed Google Scholar * Ronald N. Goldberg View author publications You can also

search for this author inPubMed Google Scholar * Namasivayam Ambalavanan View author publications You can also search for this author inPubMed Google Scholar * Cynthia Gyamfi-Bannerman View

author publications You can also search for this author inPubMed Google Scholar * Elizabeth A. Thom View author publications You can also search for this author inPubMed Google Scholar *

Rosemary D. Higgins View author publications You can also search for this author inPubMed Google Scholar CONSORTIA EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN

DEVELOPMENT NEONATAL RESEARCH NETWORK (NRN) * Abbot R. Laptook * , Lina Chalak * , Athina Pappas * , Alexis Davis * , Pablo J. Sanchez * , Krisa P. Van Meurs * , William Oh * , Seetha

Shankaran * , Angelita M. Hensman * , Scott McDonald * , Abhik Das * , Ronald N. Goldberg * , Namasivayam Ambalavanan *  & Rosemary D. Higgins EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE

OF CHILD HEALTH AND HUMAN DEVELOPMENT MATERNAL-FETAL MEDICINE UNITS (MFMU) NETWORK * Dwight J. Rouse * , Cynthia Gyamfi-Bannerman *  & Elizabeth A. Thom CONTRIBUTIONS ARL, MD made

substantial contributions to the conception of the work, acquisition and interpretation of the data, drafting the manuscript, approved the submitted version and is personally accountable for

the manuscript. LC, MD made substantial contributions to the conception of the work, acquisition and interpretation of the data, drafting the manuscript, approved the submitted version and

is personally accountable for the manuscript. AP, MD made substantial contributions to the conception of the work, acquisition and interpretation of the data, drafting the manuscript,

approved the submitted version and is personally accountable for the manuscript. AD, MD made contribution to the acquisition of the data, editing the manuscript, approved the submitted

version and is personally accountable for the manuscript. PJS, MD made contribution to the acquisition of the data, editing the manuscript, approved the submitted version and is personally

accountable for the manuscript. KPVM made contribution to the acquisition of the data, editing the manuscript, approved the submitted version and is personally accountable for the

manuscript. WO, MD made substantial contributions to the conception of the work, interpretation of the data, editing the manuscript, approved the submitted version and is personally

accountable for the manuscript. RS, MD made substantial contributions to the conception of the work, interpretation of the data, editing the manuscript, approved the submitted version and is

personally accountable for the manuscript. SS, MD made substantial contributions to the conception of the work, interpretation of the data, review of the manuscript, approved the submitted

version and is personally accountable for the manuscript. AMH, PhD, RNC-NIC made contribution to the acquisition of the data, editing the manuscript, approved the submitted version and is

personally accountable for the manuscript. DJR, MD made substantial contributions to the conception of the work, interpretation of the data, review of the manuscript, approved the submitted

version and is personally accountable for the manuscript. SM, BS made substantial contributions to the conception of the work, interpretation of the data, analysis of the data, editing the

manuscript, approved the submitted version and is personally accountable for the manuscript. AD, PhD made substantial contributions to the conception of the work, interpretation of the data,

analysis of the data, editing the manuscript, approved the submitted version and is personally accountable for the manuscript. RNG, MD made contribution to the acquisition of the data,

editing the manuscript, approved the submitted version and is personally accountable for the manuscript. NA, MD made contribution to the acquisition of the data, editing the manuscript,

approved the submitted version and is personally accountable for the manuscript. CGB, MD made substantial contributions to the conception of the work, interpretation of the data, review of

the manuscript, approved the submitted version and is personally accountable for the manuscript. EAT, MD made substantial contributions to the conception of the work, interpretation of the

data, review of the manuscript, approved the submitted version and is personally accountable for the manuscript. RDH, MD made substantial contributions to the conception of the work,

interpretation of the data, review of the manuscript, approved the submitted version and is personally accountable for the manuscript. CORRESPONDING AUTHOR Correspondence to Abbot R.

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ARTICLE Laptook, A.R., Chalak, L., Pappas, A. _et al._ The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation. _J Perinatol_ 42, 1615–1621

(2022). https://doi.org/10.1038/s41372-022-01415-4 Download citation * Received: 03 December 2021 * Revised: 21 April 2022 * Accepted: 13 May 2022 * Published: 26 May 2022 * Issue Date:

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