ABSTRACT OBJECTIVE Characterize C-reactive protein (CRP) within 72 postnatal hours in early-onset sepsis (EOS). STUDY DESIGN Secondary analysis of a prospective surveillance study of

neonates with EOS 2015–2017. We examined CRP use by center and neonatal characteristics, and CRP levels by time, neonatal characteristics, clinical signs, and pathogen. RESULTS CRP was

obtained for 96/235 neonates with EOS, which varied by center (p < 0.001). 71/95 had CRP > 10 mg/L (1 missing). Neonatal characteristics with and without CRP did not differ. There was

no relationship between CRP level and timing (_p_ = 0.41) or neonate characteristics. Median CRP was higher with ≥5 vs <5 clinical signs (56, 23 mg/L; _p_ = 0.002), and was not different

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS DETERMINANTS OF CRP MEASUREMENTS AND CRP DYNAMICS DURING EARLY NEONATAL SEPSIS WORK UP Article Open access 23 May 2025

C-REACTIVE PROTEIN TO PLATELET RATIO AS AN EARLY BIOMARKER IN DIFFERENTIATING NEONATAL LATE-ONSET SEPSIS IN NEONATES WITH PNEUMONIA Article Open access 28 March 2025 ASSOCIATION BETWEEN

PROGNOSTIC FACTORS AND THE CLINICAL DETERIORATION OF PRETERM NEONATES WITH NECROTIZING ENTEROCOLITIS Article Open access 17 August 2022 DATA AVAILABILITY Data reported in this paper may be

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Infect Dis. 2015;15:320. Article  PubMed  PubMed Central  Google Scholar  Download references FUNDING This study was supported by the Eunice Kennedy Shriver National Institute of Child

Health and Human Development cooperative agreements, which provided infrastructure and study support to the NRN (grants UG1 HD27904, UG1 HD21364, UG1 HD27853, UG1 HD40492, UG1 HD27851, UG1

HD27856, UG1 HD68278, UG1 HD36790, UG1 HD27880, UG1 HD34216, UG1 HD68270, UG1 HD53109, UG1 HD53089, UG1 HD68244, UG1 HD68263, UG1 HD40689, UG1 HD21385, and UG1 HD87229 from the NICHD), the

National Center for Advancing Translational Sciences, which provided infrastructure support to the NRN (grants UL1 TR1425, UL1 TR1117, UL1 TR454, UL1 TR1108, UL1 TR1085, UL1 TR442, UL1

TR1449, and UL1 TR42 from NCATS), and the Centers for Disease Control and Prevention, which provided study support to the NRN (Interagency Agreement #14FED1412884 from the CDC). AUTHOR

INFORMATION Author notes * A full list of members and their affiliations appears in the Supplementary Information. AUTHORS AND AFFILIATIONS * Division of Newborn Medicine, Tufts University

School of Medicine, Boston, MA, USA Ryan Kilpatrick * Department of Pediatrics, Duke University, Durham, NC, USA Rachel Greenberg & C. Michael Cotten * Social, Statistical and

Environmental Sciences Unit, RTI International, Research Triangle Park, NC, USA Nellie I. Hansen * Department of Pediatrics, Wayne State University, Detroit, MI, USA Seetha Shankaran *

Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA Waldemar A. Carlo * Department of Pediatrics, McGovern Medical School at The University of Texas Health

Science Center at Houston, Houston, TX, USA Barbara J. Stoll Authors * Ryan Kilpatrick View author publications You can also search for this author inPubMed Google Scholar * Rachel Greenberg

View author publications You can also search for this author inPubMed Google Scholar * Nellie I. Hansen View author publications You can also search for this author inPubMed Google Scholar

* Seetha Shankaran View author publications You can also search for this author inPubMed Google Scholar * Waldemar A. Carlo View author publications You can also search for this author

inPubMed Google Scholar * C. Michael Cotten View author publications You can also search for this author inPubMed Google Scholar * Barbara J. Stoll View author publications You can also

search for this author inPubMed Google Scholar CONSORTIA THE EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT NEONATAL RESEARCH NETWORK CONTRIBUTIONS RK

conceptualized and designed the study, drafted the manuscript, and interpreted the data analysis. RG contributed to the conception and design of the study, data interpretation and critical

revision of the manuscript for important intellectual content. NIH contributed to the design of the study, completed the data analysis, contributed to data interpretation, and reviewed and

revised the manuscript. SS contributed to the conception and design of the study, data interpretation, and critical revision of the manuscript for important intellectual content. WAC

contributed to the conception and design of the study, data interpretation, and critical revision of the manuscript for important intellectual content. MC contributed to the conception and

design of the study, data interpretation, and critical revision of the manuscript for important intellectual content. BJS contributed to the conception and design of the study, data

interpretation, and critical revision of the manuscript for important intellectual content. CORRESPONDING AUTHOR Correspondence to Ryan Kilpatrick. ETHICS DECLARATIONS COMPETING INTERESTS

Ryan Kilpatrick, Nellie I. Hansen, Seetha Shankaran, Waldemar A. Carlo, C. Michael Cotten, and Barbara J. Stoll have nothing to disclose. Rachel Greenberg has received support from industry

for research services (https://dcri.org/about-us/conflict-of-interest/). ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in

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governed by the terms of such publishing agreement and applicable law. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kilpatrick, R., Greenberg, R., Hansen, N.I. _et al._ Use

and utility of C-reactive protein (CRP) in neonatal early-onset sepsis: a secondary analysis of a prospective surveillance study. _J Perinatol_ 45, 139–145 (2025).

https://doi.org/10.1038/s41372-024-02064-5 Download citation * Received: 12 February 2024 * Revised: 19 June 2024 * Accepted: 25 June 2024 * Published: 05 August 2024 * Issue Date: January

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