Access through your institution Buy or subscribe Prostatic high resolution micro-ultrasound (MUS) was first described by Pavlovich et al. in 2014 [1]. Thanks to scanners operating at high

frequency (29 MHz) and the resulting real-time spatial resolution up to 70 microns (near 300% higher than existing platforms) it allows to better evaluate the microstructures and tissue

planes. Consequently, MUS is capable of highlighting the alterations of the prostatic histology that are typically associated with high-grade prostate cancer (PCa) such as loss of normal

acinar lumen and tighter cellular packing. In 2016, Ghai et al. developed the Prostate Risk Identification using MUS (PRI-MUS), a 5-point grading system to stratify MUS images according to

pelvic prosthesis, claustrophobia or cardiac implants. Moreover, it can allow imaging and biopsy as a single procedure. Finally, it can represent a way to bring PCa imaging back to urology

[3, 4]. However, despite the aforementioned premises and encouraging preliminary data, the supporting evidence is still limited. This is a preview of subscription content, access via your

institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 4 print issues and online access $259.00 per year only $64.75 per issue Learn more Buy this

article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support DATA AVAILABILITY Data sharing not applicable to this article as no datasets were generated or analyzed

during the current study. REFERENCES * Pavlovich CP, Cornish TC, Mullins JK, Fradin J, Mettee LZ, Connor JT, et al. High-resolution transrectal ultrasound: pilot study of a novel technique

for imaging clinically localized prostate cancer. Urol Oncol. 2014;32:34.e27–32. https://doi.org/10.1016/j.urolonc.2013.01.006 Article  PubMed  Google Scholar  * Ghai S, Eure G, Fradet V,

Hyndman ME, McGrath T, Wodlinger B, et al. Assessing cancer risk on novel 29 MHz micro-ultrasound images of the prostate: creation of the micro-ultrasound protocol for prostate risk

identification. J Urol. 2016;196:562–9. https://doi.org/10.1016/j.juro.2015.12.093 Article  PubMed  Google Scholar  * Klotz L, Lughezzani G, Maffei D, Sánchez A, Pereira JG, Staerman F, et

al. Comparison of micro-ultrasound and multiparametric magnetic resonance imaging for prostate cancer: a multicenter, prospective analysis. Can Urol Assoc J. 2021;15:E11–E16.

https://doi.org/10.5489/cuaj.6712. Article  PubMed  Google Scholar  * Rodríguez Socarrás ME, Gomez Rivas J, Cuadros Rivera V, Reinoso Elbers J, Llanes González L, Michel Mercado I, et al.

Prostate mapping for cancer diagnosis: the madrid protocol. transperineal prostate biopsies using multiparametric magnetic resonance imaging fusion and micro-ultrasound guided biopsies. J

Urol. 2020;204:726–33. https://doi.org/10.1097/JU.0000000000001083. Article  PubMed  Google Scholar  * Sountoulides P, Pyrgidis N, Polyzos SA, Mykoniatis I, Asouhidou E, Papatsoris A, et al.

Micro-ultrasound-guided vs multiparametric magnetic resonance imaging-targeted biopsy in the detection of prostate cancer: a systematic review and meta-analysis. J Urol 2021;205:1254–62.

https://doi.org/10.1097/JU.0000000000001639 Article  PubMed  Google Scholar  * Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, et al. EAU guidelines on

prostate cancer. Paper presented at the EAU annual congress, Amsterdam 2022. ISBN 978-94-92671-16-5. * Avolio PP, Lughezzani G, Paciotti M, Maffei D, Uleri A, Frego N, et al. The use of 29

MHz transrectal micro-ultrasound to stratify the prostate cancer risk in patients with PI-RADS III lesions at multiparametric MRI: a single institutional analysis. Urol Oncol.

2021;39:832.e1–832.e7. https://doi.org/10.1016/j.urolonc.2021.05.030. Article  PubMed  Google Scholar  * Fasulo V, Buffi NM, Regis F, Paciotti M, Persico F, Maffei D, et al. Use of

high-resolution micro-ultrasound to predict extraprostatic extension of prostate cancer prior to surgery: a prospective single-institutional study. World J Urol 2022;40:435–42.

https://doi.org/10.1007/s00345-021-03890-4 Article  CAS  PubMed  Google Scholar  * Klotz L, Andriole G, Cash H, Cooperberg M, Crawford ED, Emberton M, et al. Optimization of prostate

biopsy—micro-ultrasound versus MRI (OPTIMUM): a 3-arm randomized controlled trial evaluating the role of 29 MHz micro-ultrasound in guiding prostate biopsy in men with clinical suspicion of

prostate cancer. Contemp Clin Trials. 2022;112:106618 https://doi.org/10.1016/j.cct.2021.106618. Article  PubMed  Google Scholar  * Cash H, Hofbauer S, Shore N, Pavlovich CP, Bulang S,

Schostak M, et al. Prostate cancer detection by novice micro-ultrasound users enrolled in a training program. Soc Int Urol J. 2022;3:62–8. https://siuj.org/index.php/siuj/article/view/172.

Accessed 18 Oct 2022. Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Woman, Child and General and Specialized Surgery, University of Campania ‘Luigi

Vanvitelli’, Naples, Italy Ferdinando Fusco, Davide Arcaniolo & Celeste Manfredi * Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK Mark

Emberton * Department of Urology, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy Cosimo De Nunzio * Department of Neurosciences, Reproductive Sciences and Odontostomatology,

University of Naples Federico II, Naples, Italy Massimiliano Creta Authors * Ferdinando Fusco View author publications You can also search for this author inPubMed Google Scholar * Mark

Emberton View author publications You can also search for this author inPubMed Google Scholar * Davide Arcaniolo View author publications You can also search for this author inPubMed Google

Scholar * Cosimo De Nunzio View author publications You can also search for this author inPubMed Google Scholar * Celeste Manfredi View author publications You can also search for this

author inPubMed Google Scholar * Massimiliano Creta View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS FF and MC: conceptualization and

supervision, MH, CDN, CM and DA: writing. CORRESPONDING AUTHOR Correspondence to Ferdinando Fusco. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests.

ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. RIGHTS AND PERMISSIONS Springer

Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author

self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Reprints and permissions ABOUT THIS ARTICLE

CITE THIS ARTICLE Fusco, F., Emberton, M., Arcaniolo, D. _et al._ Prostatic high-resolution micro-ultrasound: an attractive step-forward in the management of prostate cancer patients.

_Prostate Cancer Prostatic Dis_ 26, 521–522 (2023). https://doi.org/10.1038/s41391-022-00611-9 Download citation * Received: 06 October 2022 * Revised: 18 October 2022 * Accepted: 31 October

2022 * Published: 12 December 2022 * Issue Date: September 2023 * DOI: https://doi.org/10.1038/s41391-022-00611-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to

read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing

initiative