ABSTRACT Long noncoding RNAs (lncRNAs) play a key role in human cancer development; nevertheless, the effect of lncRNA LINC00665 on the progression of gastric cancer (GC) still unclear. In

this study, we found that LINC00665 expression is upregulated in GC than normal gastric mucosa tissues and higher LINC00665 expression is associated with a poor prognosis in GC patients.

Downregulated LINC00665 inhibited GC cells proliferation, invasion, and migration in vitro. Pulmonary metastasis animal models showed that downregulated LINC00665 could reduce the lung

metastasis of GC in vivo. Tumor organoids were generated from human malignant GC tissues, downregulated LINC00665 could inhibit the growth of the organoids of GC tissues. Mechanistically,

Wnt/β-catenin signaling. In conclusion, our results identified a feedback loop between LINC00665 and YBX1 that activates Wnt/β-catenin signaling, and it may be a potential therapeutic

approach to suppress GC progression. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS LINC02139 INTERACTS WITH AND STABILIZES XIAP TO REGULATE CELL PROLIFERATION AND APOPTOSIS IN GASTRIC CANCER

Article Open access 12 November 2024 SP-1-ACTIVATED LINC01016 OVEREXPRESSION PROMOTES GASTRIC CANCER INVASION AND METASTASIS THROUGH INHIBITING EIF4A3-MEDIATED MMP9 MRNA DECAY Article Open

access 29 January 2025 ZEB1-INDUCED LINC01559 EXPEDITES CELL PROLIFERATION, MIGRATION AND EMT PROCESS IN GASTRIC CANCER THROUGH RECRUITING IGF2BP2 TO STABILIZE ZEB1 EXPRESSION Article Open

access 06 April 2021 DATA AVAILABILITY All data generated or analyzed during this study are included in this published article and its supplementary information files. The datasets are also

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Drost J. Xenograft and organoid model systems in cancer research. EMBO J. 2019;38:e101654. Article  PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS We

acknowledge the GEO and TCGA databases, Kaplan–Meier Plotter database for providing their platforms and contributors for uploading their meaningful datasets. FUNDING This work was supported

by the National Nature Science Foundation of China (81973625), the foundation of National Key Research and Development Program of China (2019YFC1316000), the foundation of Shanghai key

medical specialty construction project (ZK2019B18), the foundation of within the budget of Shanghai University of Traditional Chinese Medicine (2019LK037), and the foundation of clinical

specialized disease Construction Project of Shanghai Putuo District Municipal Health Comission (2019tszb01). AUTHOR INFORMATION Author notes * These authors contributed equally: Jie Wang,

Dongxiao Shen, Shichao Li. AUTHORS AND AFFILIATIONS * Department Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 200062, Shanghai, China Jie Wang, Dongxiao

Shen, Qingsong Zuo, Peihao Yin, Chao Chen & Teng Chen * Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese

Medicine, 200062, Shanghai, China Jie Wang, Qiuying Li, Peihao Yin, Chao Chen & Teng Chen * Shanghai Putuo Central School of Clinical Medicine, Anhui Medical University, 230022, Anhui,

China Jie Wang, Jiahao Lu, Donghao Tang, Yuejiao Feng, Peihao Yin, Chao Chen & Teng Chen * The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, 646000,

Luzhou, China Shichao Li Authors * Jie Wang View author publications You can also search for this author inPubMed Google Scholar * Dongxiao Shen View author publications You can also search

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search for this author inPubMed Google Scholar * Qingsong Zuo View author publications You can also search for this author inPubMed Google Scholar * Jiahao Lu View author publications You

can also search for this author inPubMed Google Scholar * Donghao Tang View author publications You can also search for this author inPubMed Google Scholar * Yuejiao Feng View author

publications You can also search for this author inPubMed Google Scholar * Peihao Yin View author publications You can also search for this author inPubMed Google Scholar * Chao Chen View

author publications You can also search for this author inPubMed Google Scholar * Teng Chen View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS

TC and CC conceived or designed the experiments; JW, DXS, and CSL performed the experiments and write the manuscript; QYL performed part of the animal experiments; JHL, DHT, and YJF

performed part of the cell and molecular and biology experiments; QSZ and PHY performed part of the clinical patients collect and data analysis. All authors read and approved the final

manuscript. CORRESPONDING AUTHORS Correspondence to Chao Chen or Teng Chen. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. ETHICAL APPROVAL Human samples

used in this study was obtained with informed consent and was approved by the Ethics Committee of Putuo Hospital, Shanghai University of Traditional Chinese Medicine (PTEC-A-2020-5(S)-1).

All the animal studies were performed strictly in accordance with the Animal Care Guidelines approved by the Animal Care Committee of East China Normal University. ADDITIONAL INFORMATION

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terms of such publishing agreement and applicable law. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wang, J., Shen, D., Li, S. _et al._ LINC00665 activating Wnt3a/β-catenin

signaling by bond with YBX1 promotes gastric cancer proliferation and metastasis. _Cancer Gene Ther_ 30, 1530–1542 (2023). https://doi.org/10.1038/s41417-023-00657-4 Download citation *

Received: 02 May 2023 * Revised: 16 July 2023 * Accepted: 01 August 2023 * Published: 10 August 2023 * Issue Date: November 2023 * DOI: https://doi.org/10.1038/s41417-023-00657-4 SHARE THIS

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