ABSTRACT Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within nonlymphoid tissue. They share structural and functional characteristics with secondary lymphoid

structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell region. TLS have been described in several types of cancers and are usually

associated with positive patient outcomes. However, TLS differ vastly in cellular composition and location within tissue types. In this review, we discuss factors confounding the

interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors in the context of translation to regular clinical use. Access through your institution Buy or

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VIEWED BY OTHERS HETEROGENEITY OF TERTIARY LYMPHOID STRUCTURES PREDICTS THE RESPONSE TO NEOADJUVANT THERAPY AND IMMUNE MICROENVIRONMENT CHARACTERISTICS IN TRIPLE-NEGATIVE BREAST CANCER

Article 10 December 2024 IMMUNOTHERAPY RESPONSE INDUCES DIVERGENT TERTIARY LYMPHOID STRUCTURE MORPHOLOGIES IN HEPATOCELLULAR CARCINOMA Article 25 October 2024 TERTIARY LYMPHOID STRUCTURES

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(2014). Article  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS L.M.E. was supported by the Maurice Wilkins Centre for Biodiscovery, New Zealand. J.L.R. is supported by a

Health Research Council Clinical Fellowship. We thank Hamish Angus, Ginny Niemi and Justin Tirados for critical review of the manuscript. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand Luis Munoz-Erazo, Janet L. Rhodes & Roslyn A. Kemp * Ecole Normale Superieure de Lyon, Lyon, France

and Universite Claude Bernard Lyon 1, Lyon, France Valentine C. Marion Authors * Luis Munoz-Erazo View author publications You can also search for this author inPubMed Google Scholar * Janet

L. Rhodes View author publications You can also search for this author inPubMed Google Scholar * Valentine C. Marion View author publications You can also search for this author inPubMed 

Google Scholar * Roslyn A. Kemp View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS L.M.E. and R.A.K. conceived the scope and content; all

authors contributed to writing the manuscript. CORRESPONDING AUTHOR Correspondence to Roslyn A. Kemp. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Munoz-Erazo, L., Rhodes, J.L., Marion, V.C. _et al._ Tertiary lymphoid structures in cancer –

considerations for patient prognosis. _Cell Mol Immunol_ 17, 570–575 (2020). https://doi.org/10.1038/s41423-020-0457-0 Download citation * Received: 05 February 2020 * Accepted: 22 April

2020 * Published: 15 May 2020 * Issue Date: June 2020 * DOI: https://doi.org/10.1038/s41423-020-0457-0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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KEYWORDS * tertiary lymphoid structure * prognosis * cancer * tissue