Access through your institution Buy or subscribe Interleukin-1 (IL-1), referred to as two distinct proteins, IL-1α and IL-1β, was first described almost 50 years ago.1 IL-1α and IL-1β

represent immediate early innate cytokines critically involved in alarming and activating the host defense system.2 Therefore, any impairment of IL-1 signaling pathways often leads to

devastating outcomes, such as autoimmunity and autoinflammation, dysmetabolism, cardiovascular disorders, and cancer.2 Many advances in targeting IL-1 in immune therapies have been achieved;

for example, the IL-1-blocking agents anakinra (IL-1 receptor antagonist, IL-1Ra), canakinumab (anti-IL-1β mAb), and MABp1 (anti-IL-1α mAb) have been approved for clinical use or are being

networks of IL-1-related pathways, it is still not fully understood how exactly IL-1 functions, and how to precisely rectify dysfunctional IL-1 signaling during diverse inflammatory

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Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences,

Shanghai, China Xinwen Lin, Trix Twelkmeyer & Hong Tang * IPS-GWCMC Joint Center for Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

Xinwen Lin, Trix Twelkmeyer & Hong Tang * College of Biological Sciences, University of Chinese Academy of Sciences, Beijing, China Xinwen Lin & Chao Zhang * Treatment and Research

Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China Si-Yu Wang, Ruo-Nan Xu, Fu-Sheng

Wang & Chao Zhang * Pasteurien College, Suzhou University, Jiangsu, China Hong Tang Authors * Xinwen Lin View author publications You can also search for this author inPubMed Google

Scholar * Trix Twelkmeyer View author publications You can also search for this author inPubMed Google Scholar * Si-Yu Wang View author publications You can also search for this author

inPubMed Google Scholar * Ruo-Nan Xu View author publications You can also search for this author inPubMed Google Scholar * Fu-Sheng Wang View author publications You can also search for

this author inPubMed Google Scholar * Chao Zhang View author publications You can also search for this author inPubMed Google Scholar * Hong Tang View author publications You can also search

for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Chao Zhang or Hong Tang. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lin, X., Twelkmeyer, T., Wang, SY. _et al._ An immunopathogenic perspective of interleukin-1 signaling.

_Cell Mol Immunol_ 17, 892–893 (2020). https://doi.org/10.1038/s41423-020-0475-y Download citation * Received: 09 May 2020 * Accepted: 14 May 2020 * Published: 28 May 2020 * Issue Date:

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