ABSTRACT Cancer remains one of the leading causes of death worldwide, particularly pancreatic cancer being lethal because of its aggressiveness and lack of early detection methods. A factor

that contributes to malignancy are cancer stem cell-like characteristics promoted by the tumor–stromal interaction. Given that fibroblast conditioned medium (CM) promotes sphere formation of

cancer cells, a cancer stem cell-like characteristic, its inhibitor could be a new anticancer agent. By exploring microbial cultures as a source, we found new compounds, namely,

adenopeptins B (1) and C (2), from _Acremonium_ sp. ESF00140. 1 and 2 selectively and potently inhibited the sphere formation of pancreatic cancer cells cultured in the fibroblast CM

complex V, as well as 1 and 2, strongly inhibited the sphere formation of pancreatic cancer cells cultured in fibroblast CM. The addition of 1 and 2 to pancreatic cancer cells cultured in

fibroblast CM increased reactive oxygen species (ROS) production compared with that in the control medium. In pancreatic cancer cells cultured in fibroblast CM, mitochondria significantly

influence sphere formation, and targeting their function with 1 and 2 might provide a new therapeutic approach for pancreatic cancer. Access through your institution Buy or subscribe This is

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MOLECULE FROM _SALINIVENUS IRANICA_ ACTS AS THE INHIBITOR OF CANCER STEM CELLS IN BREAST CANCER CELL LINES Article Open access 04 August 2023 1′-_O_-METHYL-AVERANTIN ISOLATED FROM THE

ENDOLICHENIC FUNGUS _JACKROGERSELLA_ SP. EL001672 SUPPRESSES COLORECTAL CANCER STEMNESS VIA SONIC HEDGEHOG AND NOTCH SIGNALING Article Open access 16 February 2023 INDUCTION OF FERROPTOSIS

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  Download references ACKNOWLEDGEMENTS We thank Ms. Yumiko Kubota, Dr. Shinya Adachi, and Dr. Kiyoko Iijima for the measurements of NMR and MS spectrum. We also thank Ms. Tamami Yoshida, Ms.

Satomi Unno, and Ms. Rina Ando for their technical assistance. We thank the Support group for Molecular Profiling of Advanced Animal Model Support by a Grant-in-Aid for Scientific Research

on Innovative Areas, Scientific Support Programs for Cancer Research, from The Ministry of Education, Culture, Sports, Science and Technology, Japan, for providing us with the SCADS

inhibitor kits. AUTHOR INFORMATION Author notes * These authors contributed equally: Daisuke Tatsuda, Masahide Amemiya. AUTHORS AND AFFILIATIONS * Laboraroty of Oncology, Institute of

Microbial Chemistry (BIKAKEN), Microbial Chemistry Research Foundation, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan Daisuke Tatsuda, Masahide Amemiya, Chisato Nosaka, Junjiro

Yoshida, Tomokazu Ohishi & Manabu Kawada * Laboratory of Molecular Structure Analysis, Institute of Microbial Chemistry (BIKAKEN), Microbial Chemistry Research Foundation, 3-14-23

Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan Ryuichi Sawa * Laboraroty of Microbiology, Institute of Microbial Chemistry (BIKAKEN), Microbial Chemistry Research Foundation, 3-14-23

Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan Hideyuki Muramatsu & Masayuki Igarashi * Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation,

18-24 Miyamoto, Numazu-shi, Shizuoka, 410-0301, Japan Tomokazu Ohishi Authors * Daisuke Tatsuda View author publications You can also search for this author inPubMed Google Scholar *

Masahide Amemiya View author publications You can also search for this author inPubMed Google Scholar * Chisato Nosaka View author publications You can also search for this author inPubMed 

Google Scholar * Ryuichi Sawa View author publications You can also search for this author inPubMed Google Scholar * Hideyuki Muramatsu View author publications You can also search for this

author inPubMed Google Scholar * Masayuki Igarashi View author publications You can also search for this author inPubMed Google Scholar * Junjiro Yoshida View author publications You can

also search for this author inPubMed Google Scholar * Tomokazu Ohishi View author publications You can also search for this author inPubMed Google Scholar * Manabu Kawada View author

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formation of pancreatic cancer cells. _J Antibiot_ 77, 73–84 (2024). https://doi.org/10.1038/s41429-023-00679-y Download citation * Received: 20 July 2023 * Revised: 27 October 2023 *

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