ABSTRACT BACKGROUND Whether to conduct enteral ecoimmunonutrition (EEIN) in patients undergoing hepatectomy remains controversial. This study aimed to systematically explore the efficacy and

safety of EEIN in patients undergoing hepatectomy. SUBJECT We performed searches in the Embase, PubMed, Medline, Cochrane Library, Chinese Scientific Journal Database (VIP), Chinese

National Knowledge Infrastructure (CNKI) and Wanfang databases. RESULTS A total of 9 randomized controlled trials (705 patients) were included. The meta-analysis revealed a significantly

shorter time to first postoperative flatus (h) (MD, −14.60; 95% CI, −16.06~−13.15; _P_ < 0.00001); lower levels of alanine aminotransferase (µmol/L) (MD, −22.26; 95% CI, −28.42~−16.10;

−79.69; 95% CI, −99.90~−59.49; _P_ < 0.00001), and interleukin-6 (pg/ml) (MD, −46.29; 95% CI, −50.24~−42.34; _P_ < 0.00001); and higher levels of immunoglobulin A (g/L) (MD, 0.24; 95%

CI, 0.14~0.35; _P_ < 0.00001), immunoglobulin G (g/L) (MD, 1.52; 95% CI, 1.22~1.82; _P_ < 0.00001), and immunoglobulin M (g/L) (MD, 0.12; 95% CI, 0.05~0.20; _P_ = 0.0007) in the EEIN

group than in the enteral or parenteral nutrition (EN/PN) groups. CONCLUSION Enteral ecoimmunonutrition support in patients undergoing hepatectomy may effectively protect liver function,

reduce serum endotoxin levels and inflammatory factors, improve the immune function of patients, and promote the recovery of postoperative gastrointestinal function, which is worthy of

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS POSTOPERATIVE NUTRITIONAL OUTCOMES AND QUALITY OF LIFE-RELATED COMPLICATIONS OF PROXIMAL _VERSUS_ TOTAL GASTRECTOMY FOR

UPPER-THIRD EARLY GASTRIC CANCER: A META-ANALYSIS Article Open access 08 December 2020 EARLY NUTRITION IS SAFE AND DOES NOT INCREASE COMPLICATIONS AFTER UPPER GASTROINTESTINAL BLEEDING—A

SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS Article Open access 10 May 2024 THE IMPACT OF PREOPERATIVE ORAL NUTRITION SUPPLEMENTATION ON OUTCOMES IN PATIENTS

UNDERGOING GASTROINTESTINAL SURGERY FOR CANCER IN LOW- AND MIDDLE-INCOME COUNTRIES: A SYSTEMATIC REVIEW AND META-ANALYSIS Article Open access 21 July 2022 DATA AVAILABILITY All data

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2021;71:209–49. https://doi.org/10.3322/caac.21660. Article  PubMed  Google Scholar  Download references FUNDING This research were supported by a program of the Department of Science and

Technology of Sichuan Province (No. 2021YFS0022) and West China Nursing Discipline Development Special Fund Project, Sichuan University (HXHL20045). The funders had no role in the study

design, data collection, analysis, decision to publish, or preparation of the paper. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * West China School of Nursing /West China Hospital, Sichuan

University, Chengdu, 610041, Sichuan Province, China Xinrong Chen, Dan Wang, Shiqi Liang & Ka Li * West China School of Nursing/Department of Gastrointestinal Surgery, West China

Hospital,Sichuan University, Chengdu, 610041, Sichuan Province, China Jie Yang Authors * Xinrong Chen View author publications You can also search for this author inPubMed Google Scholar *

Dan Wang View author publications You can also search for this author inPubMed Google Scholar * Shiqi Liang View author publications You can also search for this author inPubMed Google

Scholar * Jie Yang View author publications You can also search for this author inPubMed Google Scholar * Ka Li View author publications You can also search for this author inPubMed Google

Scholar CONTRIBUTIONS Conceptualization: CX, WD. Data curation: CX, YJ. Formal analysis: CX, LS. Project administration: LK. Resources: LK. Software: CX, WD. Supervision: LK, YJ. Writing –

original draft: CX, WD, LS. Writing – review & editing: LK, YJ. CORRESPONDING AUTHOR Correspondence to Ka Li. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

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ecoimmunonutrition support for patients undergoing hepatectomy: A meta-analysis of randomized controlled trials. _Eur J Clin Nutr_ 76, 1133–1141 (2022).

https://doi.org/10.1038/s41430-022-01073-x Download citation * Received: 18 June 2021 * Revised: 22 December 2021 * Accepted: 10 January 2022 * Published: 14 February 2022 * Issue Date:

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