ABSTRACT BACKGROUND Patients with inflammatory bowel diseases (IBD) are at risk of micronutrient deficiencies, particularly during flares. Vitamin B6 is required for the proper development

of brain, nerves, and many other parts of the body. However, limited studies are available to describe the prevalence, relevance and consequences of vitamin B6 deficiencies in IBD. We aim to

estimate the prevalence of vitamin B6 deficiencies in Crohn’s disease (CD) patients, to identify associated risk factors and to explore the alteration of intestinal microbiota related to

vitamin B6 status. METHODS A total of 360 CD patients and 55 ulcerative colitis (UC) patients from Shanghai Tenth People’s Hospital of Tongji University were included. Serum vitamin B6

patients. Logistic regression analysis showed that small bowel lesion, ileocolonic lesion (L3), extraintestinal manifestations, ileal resection, and usage of immunosuppressor were

independently associated with abnormal vitamin B6 in CD. Interestingly, the microbial structure presented significant differences between two CD groups. PICRUSt2 prediction revealed that

some enzymes and metabolic pathways between the two groups were significantly different. CONCLUSIONS Collectively, our analysis showed that vitamin B6 reduction occurred frequently in

patients with CD and affected the intestinal flora of patients. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EVALUATION OF CHANGES IN INTESTINAL MICROBIOTA IN CROHN’S DISEASE PATIENTS AFTER

ANTI-TNF ALPHA TREATMENT Article Open access 11 May 2021 HIGH PREVALENCE OF VITAMIN D DEFICIENCY IN TAIWANESE PATIENTS WITH INFLAMMATORY BOWEL DISEASE Article Open access 18 June 2024

DYSBIOSIS OF GUT MICROBIOTA IN POLISH PATIENTS WITH ULCERATIVE COLITIS: A PILOT STUDY Article Open access 25 January 2021 DATA AVAILABILITY The 16S rRNA sequencing raw data has been

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for fermentative production. Biotechnol Adv. 2017;35:31–40. https://doi.org/10.1016/j.biotechadv.2016.11.004. Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS The

authors are grateful to the participants for their involvement in the survey. FUNDING This work was supported by grants from the National Natural Science Foundation of China (82070562,

9194230064, 91942312 and 81800486) and the Shanghai Rising-Star Program (20QA1407700). AUTHOR INFORMATION Author notes * These authors contributed equally: Zhongsheng Feng, Jinghan Hua.

AUTHORS AND AFFILIATIONS * Center for IBD Research, Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China Zhongsheng Feng, 

Jinghan Hua, Fengjian Guo, Zhanju Liu, Yujie Zhao & Wei Wu Authors * Zhongsheng Feng View author publications You can also search for this author inPubMed Google Scholar * Jinghan Hua

View author publications You can also search for this author inPubMed Google Scholar * Fengjian Guo View author publications You can also search for this author inPubMed Google Scholar *

Zhanju Liu View author publications You can also search for this author inPubMed Google Scholar * Yujie Zhao View author publications You can also search for this author inPubMed Google

Scholar * Wei Wu View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS Data collation, statistical analysis and paper writing, ZF, JH and FG;

data collection, paper revision, guidance, YZ and WW; research design, funding support, paper revision and review, ZL and WW. All authors have read and agreed to the published version of the

manuscript. CORRESPONDING AUTHORS Correspondence to Yujie Zhao or Wei Wu. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. ETHICS APPROVAL AND CONSENT TO

PARTICIPATE The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Institutional Review Board for Clinical Research of the Shanghai

Tenth People’s Hospital of Tongji University. Informed consent was obtained from all subjects involved in the study. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral

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Hua, J., Guo, F. _et al._ A retrospective analysis of vitamin B6 deficiency and associated changes of gut microbes in Crohn’s disease. _Eur J Clin Nutr_ 77, 1034–1043 (2023).

https://doi.org/10.1038/s41430-023-01324-5 Download citation * Received: 26 February 2023 * Revised: 27 July 2023 * Accepted: 31 July 2023 * Published: 07 August 2023 * Issue Date: November

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