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Correction to: _Genes & Immunity_ https://doi.org/10.1038/s41435-024-00255-w, published online 24 January 2024 In this article the affiliation details for A. Cobat and B. Boisson were
incorrectly given as: A. Cobat4, B. Boisson4,5, but should have been: A. Cobat4,5,13, B. Boisson4,5,8,13, Two duplicate sentences have been deleted from the original abstract, which now
reads as follows: Primary antiphospholipid syndrome is characterized by thrombosis and autoantibodies directed against phospholipids or associated proteins. The genetic etiology of PAPS
remains unknown. We enrolled 21 patients with thromboembolic events associated to lupus anticoagulant, anticardiolipin and anti β2 glycoprotein1 autoantibodies. We performed whole exome
sequencing and a systematic variant-based analysis in genes associated with thrombosis, in candidate genes previously associated with APS or inborn errors of immunity. Data were compared to
public databases and to a control cohort of 873 non-autoimmune patients. Variants were identified following a state-of-the-art pipeline. Enrichment analysis was performed by comparing with
the control cohort. We found an absence of significant HLA bias and genetic heterogeneity in these patients, including when testing combinations of rare variants in genes encoding for
proteins involved in thrombosis and of variants in genes linked with inborn errors of immunity. These results provide evidence of genetic heterogeneity in PAPS, even in a homogenous series
of triple-positive patients. At the individual scale, a combination of variants may participate to the breakdown of B cell tolerance and to the vessel damage. The original article has been
corrected. AUTHOR INFORMATION Author notes * These authors contributed equally: A. Cobat, B. Boisson, R. Carapito, A. S. Korganow AUTHORS AND AFFILIATIONS * Department of Clinical Immunology
and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, F-67000,
Strasbourg, France A. Guffroy, L. Jacquel, V. Poindron, V. Delannoy, P. Soulas-Sprauel, T. Martin, V. Gies & A. S. Korganow * University Strasbourg, INSERM UMR - S1109, Institut
Thématique Interdisciplinaire (ITI) de Médecine de Précision de Strasbourg, Transplantex NG, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg
(FMTS), F-67000, Strasbourg, France A. Guffroy, N. Paul, A. Molitor, P. Soulas-Sprauel, T. Martin, S. Bahram, V. Gies, R. Carapito & A. S. Korganow * University de Strasbourg, Faculty
of Medicine, F-67000, Strasbourg, France A. Guffroy, L. Jacquel, T. Martin, R. Carapito & A. S. Korganow * University Paris-Cité, Imagine Institute, F-75015, Paris, France Y.
Seeleuthner, J. L. Casanova, A. Cobat & B. Boisson * Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France Y. Seeleuthner, J. L. Casanova, A.
Cobat & B. Boisson * Department of Internal Medicine, Belle-Isle Hospital, Metz, France F. Maurier * Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Universitaire,
Strasbourg, France A. C. Voegeli * St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA P. Zhang, J. L. Casanova
& B. Boisson * Laboratoire d’Immunologie, Plateau Technique de Biologie, Hôpital Universitaire, Strasbourg, France B. Nespola * Laboratoire d’exploration du HLA, Centre de Transfusion
Sanguine, Strasbourg, France M. J. Apithy * University Strasbourg, Faculty of Pharmacy, F-67400, Illkirch, France P. Soulas-Sprauel * Department of Rheumatology and Clinical Immunology,
Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany R. E. Voll Authors * A. Guffroy View author publications You can also search for this
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Scholar * R. E. Voll View author publications You can also search for this author inPubMed Google Scholar * S. Bahram View author publications You can also search for this author inPubMed
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search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to A. Guffroy or A. S. Korganow. ADDITIONAL INFORMATION The original article can be found online at
https://doi.org/10.1038/s41435-024-00255-w. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Guffroy, A., Jacquel, L., Seeleuthner, Y. _et al._
Correction: An immunogenomic exome landscape of triple positive primary antiphospholipid patients. _Genes Immun_ 25, 176 (2024). https://doi.org/10.1038/s41435-024-00261-y Download citation
* Published: 19 March 2024 * Issue Date: April 2024 * DOI: https://doi.org/10.1038/s41435-024-00261-y SHARE THIS ARTICLE Anyone you share the following link with will be able to read this
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