ABSTRACT CD8+ T cells play a critical role in specific immunity. In recent years, cell therapy has been emerging rapidly. The specific cytotoxic capabilities of these cells enable them to

precisely identify and kill cells presenting specific antigens. This has demonstrated promise in the treatment of autoimmune diseases and cancers, with wide-ranging applications and value.

However, in some diseases, such as tumors and chronic infections, T cells may adopt an exhausted phenotype, resulting in a loss of cytotoxicity and limiting their further application.

Epigenetics plays a significant role in the differentiation and regulation of gene expression in cells. There is extensive evidence indicating that epigenetic remodeling plays an important

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about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS THE EPIGENETIC LANDSCAPE OF FATE DECISIONS IN T CELLS Article 19 March

2025 EPIGENETIC REGULATION OF T CELL EXHAUSTION Article 27 May 2022 T CELLS IN HEALTH AND DISEASE Article Open access 19 June 2023 REFERENCES * Ma X, Xiao L, Liu L, Ye L, Su P, Bi E, et al.

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Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Yanjing Medical College, Capital Medical University, 101300, Beijing, China Hao Zu & Xiaoqin Chen Authors * Hao

Zu View author publications You can also search for this author inPubMed Google Scholar * Xiaoqin Chen View author publications You can also search for this author inPubMed Google Scholar

CONTRIBUTIONS Hao Zu, as the first author, proposed the research topic and conducted the literature search, analysis, illustration creation, and writing of the manuscript. Xiaoqin Chen, as

the corresponding author, provided guidance throughout the writing process, integrated feedback, and reviewed and revised the final manuscript, as well as offering support with formatting

revisions. CORRESPONDING AUTHOR Correspondence to Xiaoqin Chen. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. ADDITIONAL INFORMATION PUBLISHER’S NOTE

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this article is solely governed by the terms of such publishing agreement and applicable law. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zu, H., Chen, X. Epigenetics

behind CD8+ T cell activation and exhaustion. _Genes Immun_ 25, 525–540 (2024). https://doi.org/10.1038/s41435-024-00307-1 Download citation * Received: 06 March 2024 * Revised: 29 October

2024 * Accepted: 31 October 2024 * Published: 14 November 2024 * Issue Date: December 2024 * DOI: https://doi.org/10.1038/s41435-024-00307-1 SHARE THIS ARTICLE Anyone you share the following

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