ABSTRACT Gestational hypertension is a high-risk disease for women, and the current treatments have limited efficacies. Here, we aimed to evaluate troxerutin, which is a natural monomer of

flavone, in the treatment of gestational hypertension. Pregnant mice with or without pregnancy-induced hypertension (PIH) were treated with troxerutin (20 and 40 mg/kg) or vehicle. Blood

pressure and proteinuria were monitored during treatment. The expression of vasodilation converting enzyme (VCE), angiotensin, TNFα, IL-6, IL-1β and IL-10 was measured by enzyme-linked

immunosorbent assay (ELISA). Oxidative stress was assessed by measuring the reactive oxygen species (ROS) levels and antioxidant enzyme concentrations. Western blot analysis was used to

treatment significantly suppressed STAT3/RNF6 signaling. Overexpression of RNF6 attenuated the effects of troxerutin in ameliorating inflammation and oxidative stress. Our data support the

use of troxerutin for reducing gestational hypertension due to the role of troxerutin in reducing inflammation and oxidative stress. Access through your institution Buy or subscribe This is

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EXHIBITS AN ANTIHYPERTENSIVE EFFECT IN A RAT MODEL OF GESTATIONAL HYPERTENSION AND ACTIVATES THE NRF-2/HO-1 SIGNALING PATHWAY Article 13 January 2021 QUERCETIN ALLEVIATES ENDOTHELIAL

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AFFILIATIONS * Department of Obstetrics, Zibo Central Hospital, No. 54 of Gongqingtuan West Road, Zhangdian District, Zibo, 255000, Shandong Province, China Yuan Li, Xiuzhi Yang & Bide

Duan * Department of Scientific Education and Communication Cooperation, Zibo Central Hospital, No. 54 of Gongqingtuan West Road, Zhangdian District, Zibo, 255000, Shandong Province, China

Qi Sun * Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan, 250021, Shandong, China Yanyun

Wang Authors * Yuan Li View author publications You can also search for this author inPubMed Google Scholar * Xiuzhi Yang View author publications You can also search for this author

inPubMed Google Scholar * Qi Sun View author publications You can also search for this author inPubMed Google Scholar * Bide Duan View author publications You can also search for this author

inPubMed Google Scholar * Yanyun Wang View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Yanyun Wang. ETHICS

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CITE THIS ARTICLE Li, Y., Yang, X., Sun, Q. _et al._ The bioflavonoid troxerutin prevents gestational hypertension in mice by inhibiting STAT3 signaling. _Hypertens Res_ 44, 399–406 (2021).

https://doi.org/10.1038/s41440-020-00568-z Download citation * Received: 26 April 2020 * Revised: 13 August 2020 * Accepted: 23 September 2020 * Published: 30 October 2020 * Issue Date:

April 2021 * DOI: https://doi.org/10.1038/s41440-020-00568-z SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Troxerutin * Gestational

hypertension * Inflammation * Oxidative stress