Download PDF Author Correction Open access Published: 09 October 2024 Author Correction: Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice Sara Ranjbarvaziri1 

na1, Aliya Zeng1 na1, Iris Wu  ORCID: orcid.org/0000-0001-7515-47661, Amara Greer-Short1, Farshad Farshidfar1, Ana Budan1, Emma Xu1, Reva Shenwai1, Matthew Kozubov1, Cindy Li1, Melissa Van

Pell1, Francis Grafton1, Charles E MacKay1, Xiaomei Song1, James R Priest1, Gretchen Argast1, Mohammad A. Mandegar1, Timothy Hoey1 & …Jin Yang  ORCID: orcid.org/0000-0001-8985-13191 Show

authors Nature Communications volume 15, Article number: 8749 (2024) Cite this article

Subjects Heart failureMechanisms of diseaseTarget identificationTarget validation The Original Article was published on 26 February 2024

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-45440-7, published online 26 February 2024

The original version of this Article contained errors in Fig. 2 panel d, which occurred during final preparation of the figures and don’t affect the conclusions. In Figure 2d mistakenly

included Left Ventricle samples in the healthy control group, when only Right Ventricle samples should have been included for comparison with the HFpEF right ventricle samples. The authors

reanalyzed the data, including only right ventricle samples for the controls and right ventricle HFpEF samples.

The correct version of Fig. 2d is:

Which replaces the incorrect version of Fig. 2d:

The main text included this sentence: ‘Consistent with HFD+mTAC and HFD + L-NAME mice, HDAC6 expression was significantly higher in human hearts with HFpEF versus controls (Fig. 2d). These

findings support that changes in HDAC6 expression in HFpEF are evolutionarily conserved.’ The correct version replaces this with ‘ HDAC6 mRNA levels were trending increased (+7.4%) in human

hearts with HFpEF versus controls, although this difference is not statistically significant (Fig. 2d). Future studies should incorporate more data points to achieve a robust statistical

comparison. Furthermore, given protein levels can provide additional insights into the functional status of HDAC6 beyond mRNA expression, it is crucial to analyze HDAC6 protein levels in

HFpEF patient hearts, as have done in the mouse hearts of the two HFpEF models (Fig. 2b and 2c).’

The figure legend included the following text: ‘d Quantitation of HDAC6 mRNA expression in human heart tissues of healthy (n = 45) and patients with HFpEF (n = 41) from published RNA-Seq

data. Data are expressed as the mean ± SEM. Statistical significance was assessed by unpaired two-sided Student’s t test (b, d, e, g–j). ‘. The correct version replaces this with

‘Quantitation of HDAC6 mRNA expression in human heart tissues of healthy (n = 24) and patients with HFpEF (n = 41) from published RNA-Seq data. Data are expressed as the mean ± SEM.

Statistical significance was assessed by unpaired two-sided Student’s t test (b, c), or unpaired two-sided t test with Welch’s correction (d)’

The Source Data File has been updated accordingly.

This has been corrected in both the PDF and HTML versions of the Article.

These authors contributed equally: Sara Ranjbarvaziri, Aliya Zeng.

Authors and Affiliations Tenaya Therapeutics, South San Francisco, CA, USA

Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Ana Budan, Emma Xu, Reva Shenwai, Matthew Kozubov, Cindy Li, Melissa Van Pell, Francis Grafton, Charles E

MacKay, Xiaomei Song, James R Priest, Gretchen Argast, Mohammad A. Mandegar, Timothy Hoey & Jin Yang

AuthorsSara RanjbarvaziriView author publications You can also search for this author inPubMed Google Scholar

Aliya ZengView author publications You can also search for this author inPubMed Google Scholar

Iris WuView author publications You can also search for this author inPubMed Google Scholar

Amara Greer-ShortView author publications You can also search for this author inPubMed Google Scholar

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Ana BudanView author publications You can also search for this author inPubMed Google Scholar

Emma XuView author publications You can also search for this author inPubMed Google Scholar

Reva ShenwaiView author publications You can also search for this author inPubMed Google Scholar

Matthew KozubovView author publications You can also search for this author inPubMed Google Scholar

Cindy LiView author publications You can also search for this author inPubMed Google Scholar

Melissa Van PellView author publications You can also search for this author inPubMed Google Scholar

Francis GraftonView author publications You can also search for this author inPubMed Google Scholar

Charles E MacKayView author publications You can also search for this author inPubMed Google Scholar

Xiaomei SongView author publications You can also search for this author inPubMed Google Scholar

James R PriestView author publications You can also search for this author inPubMed Google Scholar

Gretchen ArgastView author publications You can also search for this author inPubMed Google Scholar

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Timothy HoeyView author publications You can also search for this author inPubMed Google Scholar

Jin YangView author publications You can also search for this author inPubMed Google Scholar

Corresponding author Correspondence to Jin Yang.

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About this articleCite this article Ranjbarvaziri, S., Zeng, A., Wu, I. et al. Author Correction: Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice. Nat Commun

15, 8749 (2024). https://doi.org/10.1038/s41467-024-52831-3

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Published: 09 October 2024

DOI: https://doi.org/10.1038/s41467-024-52831-3

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