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Access through your institution Buy or subscribe Infusion of autoantibody A12, which recognizes aldehyde dehydrogenase 4 family member A1 (ALDH4A1), in atherosclerosis-prone mice delays
atherosclerotic plaque formation, according to a new study published in _Nature_ by Almudena Ramiro and colleagues. _Ldlr_–/– mice were fed a high-fat diet (HFD) to develop atherosclerosis.
The researchers performed a high-throughput single-cell analysis of the atherosclerosis-associated antibody repertoire and identified 56 antibodies expressed by in-vivo-expanded B cell
clones in the context of the disease. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature
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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Lorenzo, C.
et al. ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies. _Nature_ https://doi.org/10.1038/s41586-020-2993-2 (2020) Article PubMed Google Scholar Download
references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Cardiology http://www.nature.com/nrcardio/ Andrew Robson Authors * Andrew Robson View author publications You can also
search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Andrew Robson. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
Robson, A. Plaque-reactive autoantibody A12 protects against atherosclerosis. _Nat Rev Cardiol_ 18, 151 (2021). https://doi.org/10.1038/s41569-020-00494-0 Download citation * Published: 15
December 2020 * Issue Date: March 2021 * DOI: https://doi.org/10.1038/s41569-020-00494-0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get
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