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Access through your institution Buy or subscribe Disease relapse in paediatric patients with B cell acute lymphoblastic leukaemia (B-ALL) receiving CD19-targeted chimeric antigen receptor
(CAR) T cells is generally associated with loss of CAR T cell persistence and/or loss of CD19 expression. To overcome this limitation, several sequential or combinatorial approaches using
CD22-targeted CAR T cells have been tested; however, responses are usually not durable. Now, data from a phase II trial reveal that co-administration of CD19-targeted and CD22-targeted CAR T
cells is safe and effective in relapsed and/or refractory (R/R) B-ALL. A total of 78 patients underwent consolidative transplantation, which was associated with improved EFS (85.0% versus
69.2% without transplantation; _P_ = 0.03) but not with significant differences in OS (91.3% versus 85.0%; _P_ = 0.4) at 12 months. This is a preview of subscription content, access via your
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Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional
subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Wang, T. et al. Coadministration of CD19- and CD22-directed chimeric antigen receptor T-cell therapy in
childhood B-cell acute lymphoblastic leukemia: a single-arm, multicenter, phase II trial. _J. Clin. Oncol._ https://doi.org/10.1200/JCO.22.01214 (2022) Article Google Scholar Download
references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc Diana Romero Authors * Diana Romero View author publications You can
also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Diana Romero. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
Romero, D. Promise with co-administration of CAR T cells. _Nat Rev Clin Oncol_ 20, 1 (2023). https://doi.org/10.1038/s41571-022-00713-2 Download citation * Published: 22 November 2022 *
Issue Date: January 2023 * DOI: https://doi.org/10.1038/s41571-022-00713-2 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link
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