Play all audios:
Access through your institution Buy or subscribe A new study shows that obesity can result from decreased leptin gene (_LEP_) expression. Olof Dallner, Jeffrey Friedman and colleagues report
that defects in _LEP_ expression can cause a form of obesity that is characterized by reduced circulating levels of leptin. The authors found that this form of obesity is responsive to
leptin therapy. In the present study, the authors used transgenic leptin–luciferase reporter mice to map _cis_-elements that regulate _LEP_. “It is necessary to study _LEP_ expression in
vivo because the level of expression of the gene is approximately 1000 fold lower in cultured cells than in fat cells in vivo,” says Friedman. This is a preview of subscription content,
access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99
/ 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on
SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about
institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Dallner, O. S. et al. Dysregulation of a long noncoding RNA reduces leptin leading to a
leptin-responsive form of obesity. _Nat. Med._ 25, 507–516 (2019) Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Endocrinology
http://www.nature.com/nrendo/ Alan Morris Authors * Alan Morris View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to
Alan Morris. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Morris, A. Subtyping obesity. _Nat Rev Endocrinol_ 15, 316 (2019).
https://doi.org/10.1038/s41574-019-0201-y Download citation * Published: 04 April 2019 * Issue Date: June 2019 * DOI: https://doi.org/10.1038/s41574-019-0201-y SHARE THIS ARTICLE Anyone you
share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the
Springer Nature SharedIt content-sharing initiative