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Access through your institution Buy or subscribe The oestrogen negative feedback pathway is known to be crucial to fertility in mammals. However, the underlying mechanisms have been unclear.
New research published in _Nature Communications_ details the central role that oestrogen receptor alpha (ESR1) in the kisspeptin neurons of the arcuate nucleus (ARN) has in this feedback
pathway. Previous studies looking at the neural mechanisms of the oestrogen feedback pathway have been challenging, as it is difficult to separate the effects in the brain from the effects
of 17β-oestradiol on the pituitary gland. The authors of the _Nature Communications_ paper used a range of methods to circumvent this limitation. They used GCaMP fibre photometry in
combination with a range of CRISPR-mediated gene editing. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature
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ARTICLE * McQuillan, H. J. et al. Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice. _Nat. Commun._ 13, 7433 (2022) Article CAS
Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Endocrinology http://www.nature.com/nrendo/ Claire Greenhill Authors * Claire Greenhill View
author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Claire Greenhill. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT
THIS ARTICLE CITE THIS ARTICLE Greenhill, C. Uncovering how the GnRH pulse generator is controlled in female mice. _Nat Rev Endocrinol_ 19, 63 (2023).
https://doi.org/10.1038/s41574-022-00795-z Download citation * Published: 22 December 2022 * Issue Date: February 2023 * DOI: https://doi.org/10.1038/s41574-022-00795-z SHARE THIS ARTICLE
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