Owing to its simplicity, dextran sulfate sodium (DSS)-induced colitis is one of the most widely used mouse models of colitis. However, the severity of inflammation varies from one experiment

to another. In a new study, Forster and colleagues have provided new insights into the DSS model by revealing specific microbial taxa that underlie disease variability. Access through your

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Rolhion who designed the original version of Fig. 1 and helped with preparing the manuscript. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Gastroenterology Department, Sorbonne Université,

INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Paris, France Nicolas Benech & Harry Sokol * French Group of Faecal Microbiota Transplantation (GFTF),

Paris, France Nicolas Benech & Harry Sokol * Paris Center for Microbiome Medicine, Fédération Hospitalo-Universitaire, Paris, France Nicolas Benech & Harry Sokol * INRAe, UMR1319

Micalis & AgroParisTech, Jouy en Josas, France Harry Sokol Authors * Nicolas Benech View author publications You can also search for this author inPubMed Google Scholar * Harry Sokol

View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Harry Sokol. ETHICS DECLARATIONS COMPETING INTERESTS H.S. received

consultancy, or lecture fees, from Carenity, Abbvie, Astellas, Danone, Ferring, Mayoly Spindler, MSD, Novartis, Roche, Tillots, Enterome, Maat, BiomX, Biose, Novartis, and Takeda and is

also a co-founder of Exeliom Bioscience. N.B. received lecture fees from Tillots and travel grants from Pfizer. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Benech, N., Sokol, H. Specific gut microbiota taxa as a key source of variability in colitis model. _Nat Rev Gastroenterol Hepatol_ 19, 491–492 (2022).

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