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Access through your institution Buy or subscribe Ageing is associated with increased myelopoiesis in the bone marrow; this has been linked to the enhanced systemic inflammation that is seen
with age but the mechanisms involved are ill-defined. Reporting in _Immunity_, Pioli et al. now describe a role for plasma cells in driving increased myelopoiesis in the bone marrow of older
mice. To identify which progenitor stages are regulated by plasma cells, the authors used an in vitro system in which lymphoid-HSCs, myeloid-HSCs, myeloid progenitor cells and common
lymphoid progenitors (CLPs) were cultured with stromal cells and plasma cells from young or old mice. They found that old (but not young) plasma cells increased the proportions of CD11b+
(myeloid) cells and reduced the proportions of CD19+ (lymphoid) cells obtained from the lymphoid-HSC and myeloid-HSC cultures. Furthermore, old plasma cells enhanced CD11b+ cell production
from myeloid progenitor cell cultures and inhibited CD19+ cell production in CLP cultures. Therefore, plasma cells from old mice enhance myeloid cell production both in vivo and in vitro.
However, unlike what had been observed in vivo, old plasma cells also reduced lymphoid cell production in this in vitro system. This is a preview of subscription content, access via your
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Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional
subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Pioli, P. D. et al. Plasma cells are obligate effectors of enhanced myelopoiesis in aging bone marrow.
_Immunity_ https://doi.org/10.1016/j.immuni.2019.06.006 (2019) Article PubMed Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Immunology
http://www.nature.com/nri/ Yvonne Bordon Authors * Yvonne Bordon View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to
Yvonne Bordon. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bordon, Y. Old plasma cell network supports the myeloid lineage. _Nat Rev Immunol_ 19,
534–535 (2019). https://doi.org/10.1038/s41577-019-0205-9 Download citation * Published: 23 July 2019 * Issue Date: September 2019 * DOI: https://doi.org/10.1038/s41577-019-0205-9 SHARE THIS
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