Play all audios:
Access through your institution Buy or subscribe The early human gut microbiota affects health and disease states during life, and research efforts have focused on understanding initial
colonization, development and function. Bittinger, Zemel, Wu and colleagues studied the gut microbiome, proteome and metabolome in the faecal samples of newborns taken during their first
days after birth. By 16 h, bacteria became detectable using molecular methods, and the detected bacterial strains did not exhibit a genomic signature. The proteomic and the faecal
metabolomic profiles were altered upon the appearance of bacteria and were consistent with anaerobic rather than aerobic bacterial growth; several amino acids decreased whereas several
products of bacterial fermentation increased with the detection of bacteria. In sum, the findings of the study suggest a biochemical shift in the infant samples associated with the
appearance of bacteria. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio
journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per
year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated
during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Bittinger, K., Zemel,
B. S. & Wu, G. D. et al. Bacterial colonization reprograms the neonatal gut metabolome. _Nat. Micro._ https://doi.org/10.1038/s41564-020-0694-0 (2020) Article Google Scholar Download
references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Microbiology http://www.nature.com/nrmicro/ Andrea Du Toit Authors * Andrea Du Toit View author publications You can
also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Andrea Du Toit. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS
ARTICLE Du Toit, A. Early changes. _Nat Rev Microbiol_ 18, 316 (2020). https://doi.org/10.1038/s41579-020-0370-7 Download citation * Published: 22 April 2020 * Issue Date: June 2020 * DOI:
https://doi.org/10.1038/s41579-020-0370-7 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative