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A new study used genome-wide association data and Mendelian randomization to investigate associations between the gut microbiome and metabolic traits. The researchers demonstrate that host
genetic variants influence levels of the short-chain fatty acids butyrate and propionate in the gut, which in turn modulate host glycaemic metabolism. Access through your institution Buy or
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subscriptions * Read our FAQs * Contact customer support REFERENCES * Lau, W. L. et al. Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins. _Clin.
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funded by American Heart Association grant 17IRG33410803 and National Institutes of Health–National Institute of Neurological Disorders and Stroke grant R01 NS20989. AUTHOR INFORMATION
AUTHORS AND AFFILIATIONS * Division of Nephrology, Department of Medicine, University of California, Irvine, CA, USA Wei Ling Lau & Nosratola D. Vaziri Authors * Wei Ling Lau View author
publications You can also search for this author inPubMed Google Scholar * Nosratola D. Vaziri View author publications You can also search for this author inPubMed Google Scholar
CORRESPONDING AUTHORS Correspondence to Wei Ling Lau or Nosratola D. Vaziri. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS
Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lau, W.L., Vaziri, N.D. Gut microbial short-chain fatty acids and the risk of diabetes. _Nat Rev Nephrol_ 15, 389–390 (2019).
https://doi.org/10.1038/s41581-019-0142-7 Download citation * Published: 27 March 2019 * Issue Date: July 2019 * DOI: https://doi.org/10.1038/s41581-019-0142-7 SHARE THIS ARTICLE Anyone you
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