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Access through your institution Buy or subscribe Ectopic lipid accumulation in the kidney and liver promotes organ injury and dysfunction. Now, Ling Zheng, Kun Huang and colleagues report a
new regulatory pathway that modulates lipid accumulation in the kidney and liver by controlling serine production in the kidney. Analysis of existing kidney disease gene expression datasets
suggested a potential link between UTX and 3-phosphoglycerate dehydrogenase (PHGDH), which is a rate-limiting enzyme in the synthesis of serine. Compared with healthy individuals, patients
with obesity or diabetic kidney disease had lower levels of _PHGDH_ in their kidneys. Accordingly, the researchers found that serum serine levels were lower in patients with obesity-related
kidney disease and correlated positively with estimated glomerular filtration rate. By contrast, the kidneys of UTX-deficient mice fed an HFD had significantly higher levels of PHGDH protein
(but not mRNA) and serine than controls. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other
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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Chen, H.
et al. Renal UTX–PHGDH–serine axis regulates metabolic disorders in the kidney and liver. _Nat. Commun._ 13, 3835 (2022) Article CAS Google Scholar Download references AUTHOR INFORMATION
AUTHORS AND AFFILIATIONS * Nature Reviews Nephrology http://www.nature.com/nrneph Monica Wang Authors * Monica Wang View author publications You can also search for this author inPubMed
Google Scholar CORRESPONDING AUTHOR Correspondence to Monica Wang. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wang, M. UTX regulates accumulation of
lipids via kidney serine. _Nat Rev Nephrol_ 18, 543 (2022). https://doi.org/10.1038/s41581-022-00615-7 Download citation * Published: 26 July 2022 * Issue Date: September 2022 * DOI:
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